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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Detection of tumor necrosis factor-alpha-positive cells in cerebrospinal fluid of patients with HTLV-I-associated myelopathy.

Tumor necrosis factor (TNF)-alpha-positive cells constituted 1.6-18% and 8.2-23.5% of the total number of cerebrospinal fluid cells from six of 12 patients with HTLV-I-associated myelopathy and in all samples obtained from inflammatory cases, respectively. However, in non-inflammatory cases no TNF-alpha-positive cells were detected. These results suggest that some of the infiltrating CSF cells produce TNF-alpha, which plays a role in host immune defenses against causative agents including HTLV-I and in lesion formation within the central nervous system in inflammatory diseases.[1]

References

  1. Detection of tumor necrosis factor-alpha-positive cells in cerebrospinal fluid of patients with HTLV-I-associated myelopathy. Nakamura, S., Nagano, I., Yoshioka, M., Shimazaki, S., Onodera, J., Kogure, K. J. Neuroimmunol. (1993) [Pubmed]
 
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