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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The major fat-globule membrane proteins, bovine components 15/16 and guinea-pig GP 55, are homologous to MGF-E8, a murine glycoprotein containing epidermal growth factor-like and factor V/VIII-like sequences.

The glycoproteins, Components 15/16 and GP 55, were partially purified from bovine and guinea-pig fat-globule membrane (FGM), respectively. Peptides prepared from immunoblots of Component 16 and GP 55, were shown by sequencing, to be similar to mouse MFG-E8 and a human milk protein of M(r) 46,000. Both of these latter proteins are associated with the FGM and contain epidermal growth factor-like domains and/or factor V/VIII-like sequences. These data complement earlier biochemical studies on the biosynthesis, tissue distribution and topology of Components 15/16 and GP 55, and indicate that MFG-E8-like proteins are expressed on the apical surfaces of mammary epithelial cells and are secreted both in a soluble form and as major components of the FGM in diverse species. The possible function of these proteins in lactation and in mammary and neonatal development is discussed.[1]

References

  1. The major fat-globule membrane proteins, bovine components 15/16 and guinea-pig GP 55, are homologous to MGF-E8, a murine glycoprotein containing epidermal growth factor-like and factor V/VIII-like sequences. Mather, I.H., Banghart, L.R., Lane, W.S. Biochem. Mol. Biol. Int. (1993) [Pubmed]
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