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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Eosinophilic pneumonia and respiratory failure associated with a trazodone overdose.

Drug-induced eosinophilic lung disease commonly presents as a simple pulmonary eosinophilia-like syndrome consisting of transient pulmonary infiltrates, peripheral eosinophilia, and mild pulmonary symptoms that disappear promptly upon withdrawal of the offending medication. However, a more fulminant presentation most resembling acute eosinophilic pneumonia has been recently described. We present a patient with BAL-confirmed eosinophilic pneumonia (EP) and respiratory failure after a trazodone overdose. This is the first case of EP associated with trazodone and only the third drug-mediated EP reported to precipitate respiratory failure.[1]


  1. Eosinophilic pneumonia and respiratory failure associated with a trazodone overdose. Salerno, S.M., Strong, J.S., Roth, B.J., Sakata, V. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
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