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MeSH Review

Pulmonary Eosinophilia

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Disease relevance of Pulmonary Eosinophilia


High impact information on Pulmonary Eosinophilia


Chemical compound and disease context of Pulmonary Eosinophilia


Biological context of Pulmonary Eosinophilia


Anatomical context of Pulmonary Eosinophilia


Gene context of Pulmonary Eosinophilia

  • Administration of IL-12 (1 microgram/d x 5 d) at the time of a single antigen challenge abolished the airway hyperresponsiveness and pulmonary eosinophilia and promoted an increase in interferon (IFN) gamma and decreases in IL-4 and IL-5 expression [23].
  • In support of this, mice genetically deficient for VCAM-1 and intercellular adhesion molecule-1 failed to develop pulmonary eosinophilia [24].
  • Pulmonary eosinophilia was absent in both IL-4 KO and IL-10 KO mice compared with WT mice [25].
  • Second, in order to address the specific role of eotaxin-2 in IL-13-induced pulmonary eosinophilia, we generated eotaxin-2 gene-deficient mice by homologous recombination [26].
  • Using two different protocols of allergen challenge, we demonstrate that absence of CCR8 does not affect the development of pulmonary eosinophilia and Th2 cytokine responses [27].

Analytical, diagnostic and therapeutic context of Pulmonary Eosinophilia


  1. Eliminating a region of respiratory syncytial virus attachment protein allows induction of protective immunity without vaccine-enhanced lung eosinophilia. Sparer, T.E., Matthews, S., Hussell, T., Rae, A.J., Garcia-Barreno, B., Melero, J.A., Openshaw, P.J. J. Exp. Med. (1998) [Pubmed]
  2. Distinct types of lung disease caused by functional subsets of antiviral T cells. Alwan, W.H., Kozlowska, W.J., Openshaw, P.J. J. Exp. Med. (1994) [Pubmed]
  3. Human eosinophil major basic protein induces airway constriction and airway hyperresponsiveness in primates. Gundel, R.H., Letts, L.G., Gleich, G.J. J. Clin. Invest. (1991) [Pubmed]
  4. Eosinophilic pneumonia and respiratory failure associated with a trazodone overdose. Salerno, S.M., Strong, J.S., Roth, B.J., Sakata, V. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  5. Sulfadoxine specific lymphocyte transformation in a patient with eosinophilic pneumonia induced by sulfadoxine-pyrimethamine (Fansidar). Daniel, P.T., Holzschuh, J., Berg, P.A. Thorax (1989) [Pubmed]
  6. Clofibrate and eosinophilic pneumonia. Hendrickson, R.M., Simpson, F. JAMA (1982) [Pubmed]
  7. Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction. Blackburn, M.R., Volmer, J.B., Thrasher, J.L., Zhong, H., Crosby, J.R., Lee, J.J., Kellems, R.E. J. Exp. Med. (2000) [Pubmed]
  8. Atypical pulmonary eosinophilia is mediated by a specific amino acid sequence of the attachment (G) protein of respiratory syncytial virus. Tebbey, P.W., Hagen, M., Hancock, G.E. J. Exp. Med. (1998) [Pubmed]
  9. Virus-specific CD8+ T lymphocytes downregulate T helper cell type 2 cytokine secretion and pulmonary eosinophilia during experimental murine respiratory syncytial virus infection. Srikiatkhachorn, A., Braciale, T.J. J. Exp. Med. (1997) [Pubmed]
  10. Pulmonary eosinophilia associated with dapsone. Janier, M., Guillevin, L., Badillet, G. Lancet (1994) [Pubmed]
  11. Eotaxin represents the principal eosinophil chemoattractant in a novel murine asthma model induced by house dust containing cockroach allergens. Kim, J., Merry, A.C., Nemzek, J.A., Bolgos, G.L., Siddiqui, J., Remick, D.G. J. Immunol. (2001) [Pubmed]
  12. Steroid-refractory neonatal eosinophilic pneumonia responsive to cyclosporin A. Morton, R.L., Shoemaker, L.R., Eid, N.S. Am. J. Respir. Crit. Care Med. (1999) [Pubmed]
  13. Eotaxin and RANTES enhance 5-oxo-6,8,11,14-eicosatetraenoic acid-induced eosinophil chemotaxis. Powell, W.S., Ahmed, S., Gravel, S., Rokach, J. J. Allergy Clin. Immunol. (2001) [Pubmed]
  14. Pulmonary function in tropical eosinophilia before and after treatment with diethylcarbamazine. Nesarajah, M.S. Thorax (1975) [Pubmed]
  15. Urinary eosinophil-derived neurotoxin/protein X: a simple method for assessing eosinophil degranulation in vivo. Cottin, V., Deviller, P., Tardy, F., Cordier, J.F. J. Allergy Clin. Immunol. (1998) [Pubmed]
  16. Immune responses to the nonglycosylated ectodomain of respiratory syncytial virus attachment glycoprotein mediate pulmonary eosinophilia in inbred strains of mice with different MHC haplotypes. Hancock, G.E., Tebbey, P.W., Scheuer, C.A., Pryharski, K.S., Heers, K.M., LaPierre, N.A. J. Med. Virol. (2003) [Pubmed]
  17. Acute eosinophilic pneumonia associated with intramuscular administration of progesterone as luteal phase support after IVF: case report. Bouckaert, Y., Robert, F., Englert, Y., De Backer, D., De Vuyst, P., Delbaere, A. Hum. Reprod. (2004) [Pubmed]
  18. Genetic polymorphisms of eosinophil-derived neurotoxin and eosinophil cationic protein in tropical pulmonary eosinophilia. Kim, Y.J., Kumaraswami, V., Choi, E., Mu, J., Follmann, D.A., Zimmerman, P., Nutman, T.B. Am. J. Trop. Med. Hyg. (2005) [Pubmed]
  19. OX40 ligation on activated T cells enhances the control of Cryptococcus neoformans and reduces pulmonary eosinophilia. Humphreys, I.R., Edwards, L., Walzl, G., Rae, A.J., Dougan, G., Hill, S., Hussell, T. J. Immunol. (2003) [Pubmed]
  20. Th type 1-stimulating activity of lung macrophages inhibits Th2-mediated allergic airway inflammation by an IFN-gamma-dependent mechanism. Tang, C., Inman, M.D., van Rooijen, N., Yang, P., Shen, H., Matsumoto, K., O'Byrne, P.M. J. Immunol. (2001) [Pubmed]
  21. In vivo expression of CD69 on lung eosinophils in eosinophilic pneumonia: CD69 as a possible activation marker for eosinophils. Nishikawa, K., Morii, T., Ako, H., Hamada, K., Saito, S., Narita, N. J. Allergy Clin. Immunol. (1992) [Pubmed]
  22. Elevated levels of thymus- and activation-regulated chemokine in bronchoalveolar lavage fluid from patients with eosinophilic pneumonia. Miyazaki, E., Nureki, S., Fukami, T., Shigenaga, T., Ando, M., Ito, K., Ando, H., Sugisaki, K., Kumamoto, T., Tsuda, T. Am. J. Respir. Crit. Care Med. (2002) [Pubmed]
  23. Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. Gavett, S.H., O'Hearn, D.J., Li, X., Huang, S.K., Finkelman, F.D., Wills-Karp, M. J. Exp. Med. (1995) [Pubmed]
  24. Eosinophil recruitment to the lung in a murine model of allergic inflammation. The role of T cells, chemokines, and adhesion receptors. Gonzalo, J.A., Lloyd, C.M., Kremer, L., Finger, E., Martinez-A, C., Siegelman, M.H., Cybulsky, M., Gutierrez-Ramos, J.C. J. Clin. Invest. (1996) [Pubmed]
  25. Distinct roles for IL-4 and IL-10 in regulating T2 immunity during allergic bronchopulmonary mycosis. Hernandez, Y., Arora, S., Erb-Downward, J.R., McDonald, R.A., Toews, G.B., Huffnagle, G.B. J. Immunol. (2005) [Pubmed]
  26. Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation. Pope, S.M., Fulkerson, P.C., Blanchard, C., Akei, H.S., Nikolaidis, N.M., Zimmermann, N., Molkentin, J.D., Rothenberg, M.E. J. Biol. Chem. (2005) [Pubmed]
  27. CCR8 is not essential for the development of inflammation in a mouse model of allergic airway disease. Chung, C.D., Kuo, F., Kumer, J., Motani, A.S., Lawrence, C.E., Henderson, W.R., Venkataraman, C. J. Immunol. (2003) [Pubmed]
  28. Mucosal delivery of a respiratory syncytial virus CTL peptide with enterotoxin-based adjuvants elicits protective, immunopathogenic, and immunoregulatory antiviral CD8+ T cell responses. Simmons, C.P., Hussell, T., Sparer, T., Walzl, G., Openshaw, P., Dougan, G. J. Immunol. (2001) [Pubmed]
  29. Circulating parasite antigen(s) in lymphatic filariasis: use of monoclonal antibodies to phosphocholine for immunodiagnosis. Lal, R.B., Paranjape, R.S., Briles, D.E., Nutman, T.B., Ottesen, E.A. J. Immunol. (1987) [Pubmed]
  30. Elevated chemokine levels in bronchoalveolar lavage fluid of patients with eosinophilic pneumonia. Katoh, S., Matsumoto, N., Fukushima, K., Mukae, H., Kadota, J.I., Kohno, S., Matsukura, S. J. Allergy Clin. Immunol. (2000) [Pubmed]
  31. Generation of atypical pulmonary inflammatory responses in BALB/c mice after immunization with the native attachment (G) glycoprotein of respiratory syncytial virus. Hancock, G.E., Speelman, D.J., Heers, K., Bortell, E., Smith, J., Cosco, C. J. Virol. (1996) [Pubmed]
  32. Proteasome inhibition: A novel mechanism to combat asthma. Elliott, P.J., Pien, C.S., McCormack, T.A., Chapman, I.D., Adams, J. J. Allergy Clin. Immunol. (1999) [Pubmed]
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