The inhibitory effect of astragalus membranaceus on coxsackie B-3 virus RNA replication.
Using mice infected with coxsackie B-3 virus (CVB3) as a viral myocarditis model, we observed the inhibitory effect of Astragalus membranaceus (AM) on CVB3-RNA replication in myocardial tissue of mice by RNA-RNA in situ hybridization with negative-strand RNA probes labelled with 35S and quantitative imaging analysis of positive signals. The mechanism of its effect on CVB3-RNA replication has been investigated by detection of beta-interferon (beta-IFN) as well. Results showed that the copy numbers of CVB3-RNA as well as the histologic scores (necrosis) in myocardial tissues of infected-AM treated mice were significantly lower than those in infected and normal saline treated mice, suggesting that AM could inhibit the replication of CVB3-RNA, but its effect on CVB3-RNA replication had no correlation with induction of beta-IFN.[1]References
- The inhibitory effect of astragalus membranaceus on coxsackie B-3 virus RNA replication. Peng, T., Yang, Y., Riesemann, H., Kandolf, R. Chin. Med. Sci. J. (1995) [Pubmed]
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