The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Myocarditis


High impact information on Myocarditis

  • A histologic diagnosis of myocarditis was made in 63 of the patients with dilated cardiomyopathy (83 percent) [6].
  • After resolution of acute myocarditis, DC-immunized mice developed heart failure, and TLR stimulation of these mice resulted in relapse of inflammatory infiltrates [7].
  • Pancreatic expression of interferon-gamma protects mice from lethal coxsackievirus B3 infection and subsequent myocarditis [8].
  • Here we show the etiologic importance of serine elastase activity in the pathophysiology of acute viral myocarditis and the therapeutic efficacy of an elastase inhibitor [2].
  • Homozygous MIP-1 alpha mutant (-/-) mice were resistant to Coxsackievirus-induced myocarditis seen in infected wild-type (+/+) mice [9].

Chemical compound and disease context of Myocarditis


Biological context of Myocarditis


Anatomical context of Myocarditis

  • Restricted usage of T cell receptor V alpha-V beta genes in infiltrating cells in the hearts of patients with acute myocarditis and dilated cardiomyopathy [20].
  • Therefore, we postulate that vesnarinone exerted its beneficial effects through an inhibition of natural killer cell activity, and that it serves as an immunomodulator providing new therapeutic possibilities for the treatment of viral myocarditis and/or immunological disorders [5].
  • Clinical and prognostic significance of detection of enteroviral RNA in the myocardium of patients with myocarditis or dilated cardiomyopathy [21].
  • CONCLUSIONS: cTnI was superior to CK-MB for detection of myocyte injury in myocarditis, and cTnI elevations were substantially more common in the first month after the onset of heart failure symptoms [22].
  • These findings provide for the first time the direct evidence that the first wave of cell infiltration in hearts mainly consists of killer cells and strongly suggests that perforin plays, in part, an important role in myocardial cell damage involved in acute viral myocarditis [23].

Gene context of Myocarditis


Analytical, diagnostic and therapeutic context of Myocarditis


  1. Acute cardiac events temporally related to cocaine abuse. Isner, J.M., Estes, N.A., Thompson, P.D., Costanzo-Nordin, M.R., Subramanian, R., Miller, G., Katsas, G., Sweeney, K., Sturner, W.Q. N. Engl. J. Med. (1986) [Pubmed]
  2. A serine elastase inhibitor reduces inflammation and fibrosis and preserves cardiac function after experimentally-induced murine myocarditis. Lee, J.K., Zaidi, S.H., Liu, P., Dawood, F., Cheah, A.Y., Wen, W.H., Saiki, Y., Rabinovitch, M. Nat. Med. (1998) [Pubmed]
  3. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Dent, A.L., Shaffer, A.L., Yu, X., Allman, D., Staudt, L.M. Science (1997) [Pubmed]
  4. Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice. Pummerer, C.L., Luze, K., Grässl, G., Bachmaier, K., Offner, F., Burrell, S.K., Lenz, D.M., Zamborelli, T.J., Penninger, J.M., Neu, N. J. Clin. Invest. (1996) [Pubmed]
  5. Treatment of virus-induced myocardial injury with a novel immunomodulating agent, vesnarinone. Suppression of natural killer cell activity and tumor necrosis factor-alpha production. Matsui, S., Matsumori, A., Matoba, Y., Uchida, A., Sasayama, S. J. Clin. Invest. (1994) [Pubmed]
  6. Incidence of dilated cardiomyopathy and detection of HIV in myocardial cells of HIV-positive patients. Gruppo Italiano per lo Studio Cardiologico dei Pazienti Affetti da AIDS. Barbaro, G., Di Lorenzo, G., Grisorio, B., Barbarini, G. N. Engl. J. Med. (1998) [Pubmed]
  7. Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity. Eriksson, U., Ricci, R., Hunziker, L., Kurrer, M.O., Oudit, G.Y., Watts, T.H., Sonderegger, I., Bachmaier, K., Kopf, M., Penninger, J.M. Nat. Med. (2003) [Pubmed]
  8. Pancreatic expression of interferon-gamma protects mice from lethal coxsackievirus B3 infection and subsequent myocarditis. Horwitz, M.S., La Cava, A., Fine, C., Rodriguez, E., Ilic, A., Sarvetnick, N. Nat. Med. (2000) [Pubmed]
  9. Requirement of MIP-1 alpha for an inflammatory response to viral infection. Cook, D.N., Beck, M.A., Coffman, T.M., Kirby, S.L., Sheridan, J.F., Pragnell, I.B., Smithies, O. Science (1995) [Pubmed]
  10. Myocarditis associated with methyldopa therapy. Mullick, F.G., McAllister, H.A. JAMA (1977) [Pubmed]
  11. Interleukin 1 or tumor necrosis factor can promote Coxsackie B3-induced myocarditis in resistant B10.A mice. Lane, J.R., Neumann, D.A., Lafond-Walker, A., Herskowitz, A., Rose, N.R. J. Exp. Med. (1992) [Pubmed]
  12. Enhanced expression of superoxide dismutase messenger RNA in viral myocarditis. An SH-dependent reduction of its expression and myocardial injury. Suzuki, H., Matsumori, A., Matoba, Y., Kyu, B.S., Tanaka, A., Fujita, J., Sasayama, S. J. Clin. Invest. (1993) [Pubmed]
  13. Verapamil ameliorates the clinical and pathological course of murine myocarditis. Dong, R., Liu, P., Wee, L., Butany, J., Sole, M.J. J. Clin. Invest. (1992) [Pubmed]
  14. Nitric oxide inhibits viral replication in murine myocarditis. Lowenstein, C.J., Hill, S.L., Lafond-Walker, A., Wu, J., Allen, G., Landavere, M., Rose, N.R., Herskowitz, A. J. Clin. Invest. (1996) [Pubmed]
  15. Treatment of viral myocarditis with ribavirin in an animal preparation. Matsumori, A., Wang, H., Abelmann, W.H., Crumpacker, C.S. Circulation (1985) [Pubmed]
  16. Enteroviral RNA replication in the myocardium of patients with left ventricular dysfunction and clinically suspected myocarditis. Pauschinger, M., Doerner, A., Kuehl, U., Schwimmbeck, P.L., Poller, W., Kandolf, R., Schultheiss, H.P. Circulation (1999) [Pubmed]
  17. Viral infection of the myocardium in endocardial fibroelastosis. Molecular evidence for the role of mumps virus as an etiologic agent. Ni, J., Bowles, N.E., Kim, Y.H., Demmler, G., Kearney, D., Bricker, J.T., Towbin, J.A. Circulation (1997) [Pubmed]
  18. Cardiomyopathy in dystrophin-deficient hearts is prevented by expression of a neuronal nitric oxide synthase transgene in the myocardium. Wehling-Henricks, M., Jordan, M.C., Roos, K.P., Deng, B., Tidball, J.G. Hum. Mol. Genet. (2005) [Pubmed]
  19. Myosin autoimmunity is not essential for cardiac inflammation in acute Chagas' disease. Leon, J.S., Wang, K., Engman, D.M. J. Immunol. (2003) [Pubmed]
  20. Restricted usage of T cell receptor V alpha-V beta genes in infiltrating cells in the hearts of patients with acute myocarditis and dilated cardiomyopathy. Seko, Y., Ishiyama, S., Nishikawa, T., Kasajima, T., Hiroe, M., Kagawa, N., Osada, K., Suzuki, S., Yagita, H., Okumura, K. J. Clin. Invest. (1995) [Pubmed]
  21. Clinical and prognostic significance of detection of enteroviral RNA in the myocardium of patients with myocarditis or dilated cardiomyopathy. Why, H.J., Meany, B.T., Richardson, P.J., Olsen, E.G., Bowles, N.E., Cunningham, L., Freeke, C.A., Archard, L.C. Circulation (1994) [Pubmed]
  22. Elevations of cardiac troponin I associated with myocarditis. Experimental and clinical correlates. Smith, S.C., Ladenson, J.H., Mason, J.W., Jaffe, A.S. Circulation (1997) [Pubmed]
  23. Expression of perforin in infiltrating cells in murine hearts with acute myocarditis caused by coxsackievirus B3. Seko, Y., Shinkai, Y., Kawasaki, A., Yagita, H., Okumura, K., Takaku, F., Yazaki, Y. Circulation (1991) [Pubmed]
  24. Expression of intercellular adhesion molecule-1 in murine hearts with acute myocarditis caused by coxsackievirus B3. Seko, Y., Matsuda, H., Kato, K., Hashimoto, Y., Yagita, H., Okumura, K., Yazaki, Y. J. Clin. Invest. (1993) [Pubmed]
  25. Expression of costimulatory molecules B7-1, B7-2, and CD40 in the heart of patients with acute myocarditis and dilated cardiomyopathy. Seko, Y., Takahashi, N., Ishiyama, S., Nishikawa, T., Kasajima, T., Hiroe, M., Suzuki, S., Ishiwata, S., Kawai, S., Azuma, M., Yagita, H., Okumura, K., Yazaki, Y. Circulation (1998) [Pubmed]
  26. Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis. Morita, M., Stamp, G., Robins, P., Dulic, A., Rosewell, I., Hrivnak, G., Daly, G., Lindahl, T., Barnes, D.E. Mol. Cell. Biol. (2004) [Pubmed]
  27. IL-12 receptor beta 1 and Toll-like receptor 4 increase IL-1 beta- and IL-18-associated myocarditis and coxsackievirus replication. Fairweather, D., Yusung, S., Frisancho, S., Barrett, M., Gatewood, S., Steele, R., Rose, N.R. J. Immunol. (2003) [Pubmed]
  28. Susceptibility to Coxsackievirus B3-induced chronic myocarditis maps near the murine Tcr alpha and Myhc alpha loci on chromosome 14. Traystman, M.D., Chow, L.H., McManus, B.M., Herskowitz, A., Nesbitt, M.N., Beisel, K.W. Am. J. Pathol. (1991) [Pubmed]
  29. Autoimmune myocarditis induced in mice by cardiac C-protein. Cloning of complementary DNA encoding murine cardiac C-protein and partial characterization of the antigenic peptides. Kasahara, H., Itoh, M., Sugiyama, T., Kido, N., Hayashi, H., Saito, H., Tsukita, S., Kato, N. J. Clin. Invest. (1994) [Pubmed]
  30. Extracorporeal membrane oxygenation support as a bridge to pediatric heart transplantation. del Nido, P.J., Armitage, J.M., Fricker, F.J., Shaver, M., Cipriani, L., Dayal, G., Park, S.C., Siewers, R.D. Circulation (1994) [Pubmed]
  31. Immunosuppression with high doses of cyclophosphamide reduces the severity of myocarditis but increases the mortality in murine Coxsackievirus B3 myocarditis. Kishimoto, C., Thorp, K.A., Abelmann, W.H. Circulation (1990) [Pubmed]
  32. Detection of enterovirus RNA in myocardial biopsies from patients with myocarditis and cardiomyopathy using gene amplification by polymerase chain reaction. Jin, O., Sole, M.J., Butany, J.W., Chia, W.K., McLaughlin, P.R., Liu, P., Liew, C.C. Circulation (1990) [Pubmed]
WikiGenes - Universities