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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Guanidine derivative U-37883A, inhibits mitochondrial K+ uniport.

The activity of potassium uniport in rat liver mitochondria was measured using light scattering technique (mitochondrial swelling). It was shown, that guanidine derivative, U-37883A (4-morpholinecarboxamidine-N-1-adamantyl-N'-cyclohexylhyd rochloride), was able to inhibit A23187 induced potassium uniport activity. The inhibitory effect of U-37883A on mitochondrial swelling gave an IC50 an of 89 +/- microM. No inhibition was observed with U-37883A analog, U-42069D (4-morpholinecarboxamidine), which points to the specificity of U-37883A action. It was also shown, that U-37883A acted on a different binding site in rat liver mitochondria than glibenclamide, inhibitor of the ATP sensitive potassium channel.[1]


  1. Guanidine derivative U-37883A, inhibits mitochondrial K+ uniport. Szewczyk, A., Wójcik, G., Jabłonowska, A., Nałecz, n.u.l.l. Polish journal of pharmacology. (1995) [Pubmed]
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