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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Polycondensed nitrogen heterocycles. Part 27. Indolo[3,2-c]cinnoline. Synthesis and antileukemic activity.

Indolo[3,2-c]cinnolines of type 5, variously substituted either in the indole and in the cinnoline moieties, were prepared in good overall yields, by intramolecular cyclization of indolo derivatives 4. Compounds 5a-d showed a good cytotoxic activity against FLC and K562 leukemic cell lines, both sensitive and multi-drug resistant.[1]

References

  1. Polycondensed nitrogen heterocycles. Part 27. Indolo[3,2-c]cinnoline. Synthesis and antileukemic activity. Cirrincione, G., Almerico, A.M., Diana, P., Grimaudo, S., Dattolo, G., Aiello, E., Barraja, P., Mingoia, F. Farmaco (1995) [Pubmed]
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