Disease relevance of cinnoline

• Amongst them 7-methyl-4-[(p-methyl phenyl) amino] pyrimido [5,4-c] cinnoline (2f) was the most active against Gram positive bacteria [1].

High impact information on cinnoline

• Thermal cyclization to give a cinnoline from (2-ethynylphenyl)triazenes is proposed to occur through a pericyclic pathway [2].
• On the basis of the contribution of these pharmacophores to the in vitro potency, they were ranked in the order of 5-isoquinoline > 8-quinoline = 8-quinazoline > 8-isoquinoline > or = cinnoline approximately phthalazine approximately quinoxaline approximately 5-quinoline [3].
• Structure and biological activity of some 4-amino-3-cinnolinecarboxylic acid derivatives. QSAR analysis of cinnoline derivatives with antibacterial properties [4].
• Measurement of the kinetics of adsorbed cinnoline by square-wave voltammetry [5].
• The standard redox reaction rate constant of cinnoline (1,2-benzodiazine) adsorbed to the mercury electrode in 0.9 mol L(-1) KNO(3) buffered to pH 7, 9.2, and 4.65 are k(s)=455+/-110 s(-1), 65+/-25 s(-1), and 300+/-75 s(-1), respectively [5].

Anatomical context of cinnoline

• Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives [6].

Associations of cinnoline with other chemical compounds

• Indolo[3,2-c]cinnolines of type 5, variously substituted either in the indole and in the cinnoline moieties, were prepared in good overall yields, by intramolecular cyclization of indolo derivatives 4 [7].

References