- Chymase in exocytosed rat mast cell granules effectively proteolyzes apolipoprotein AI-containing lipoproteins, so reducing the cholesterol efflux-inducing ability of serum and aortic intimal fluid. Lindstedt, L., Lee, M., Castro, G.R., Fruchart, J.C., Kovanen, P.T. J. Clin. Invest. (1996)