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Human guanylate kinase (GUK1): cDNA sequence, expression and chromosomal localisation.

Guanylate kinase (GK) catalyses the conversion of GMP to GTP as part of the cGMP cycle. In mammalian phototransduction, this cycle is essential for the regeneration of cGMP following its hydrolysis by phosphodiesterase. Mutations in different parts of this signalling cascade lead to retinal degeneration in humans. Protein studies have localized a locus for GK to a region of human chromosome 1 that also contains an autosomal recessive form of retinitis pigmentosa (RP12) and Usher's type 11a (USH2A). We report the sequence of this human GK (GUK1) and a further refinement of its localization to 1q32-41, placing it in the same interval as USH2A.[1]


  1. Human guanylate kinase (GUK1): cDNA sequence, expression and chromosomal localisation. Fitzgibbon, J., Katsanis, N., Wells, D., Delhanty, J., Vallins, W., Hunt, D.M. FEBS Lett. (1996) [Pubmed]
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