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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

The reducing ability of iron chelates by NADH-cytochrome B5 reductase or cytochrome B5 responsible for NADH-supported lipid peroxidation.

We studied iron reduction, NADH oxidation, and lipid peroxidation in the presence of iron chelates with a chelator, such as nitrilotriacetate, ADP, citrate, and pyrophosphate, in NADH-supported reconstituted system. The results showed the selectivity of NADH-cytochrome b5 reductase or cytochrome b5 towards iron chelates and the subsequent ability of this system to promote peroxidation. The lipid peroxidation was partially inhibited by superoxide dismutase. In the presence of any iron chelate, hydrogen peroxide was produced in the systems including the reductase, and the production was accompanied with an increase in NADH oxidation.[1]

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