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Cyb5r3  -  cytochrome b5 reductase 3

Rattus norvegicus

Synonyms: B5R, Cytochrome b5 reductase, Dia1, Diaphorase-1, NADH-cytochrome b5 reductase 3, ...
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Enzymatic interactions of Cyb5r3


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  1. The structure of the S127P mutant of cytochrome b5 reductase that causes methemoglobinemia shows the AMP moiety of the flavin occupying the substrate binding site. Bewley, M.C., Davis, C.A., Marohnic, C.C., Taormina, D., Barber, M.J. Biochemistry (2003) [Pubmed]
  2. Effect of extra-hepatic Walker sarcoma 256 on the synthesis and degradation of liver cytochromes P-450 and b5. Raw, I. Braz. J. Med. Biol. Res. (1983) [Pubmed]
  3. Localization of nitric oxide synthase in the brain stem neural circuit controlling esophageal peristalsis in rats. Wiedner, E.B., Bao, X., Altschuler, S.M. Gastroenterology (1995) [Pubmed]
  4. Colitis and interleukin 1beta up-regulate inducible nitric oxide synthase and superoxide dismutase in rat myenteric neurons. Valentine, J.F., Tannahill, C.L., Stevenot, S.A., Sallustio, J.E., Nick, H.S., Eaker, E.Y. Gastroenterology (1996) [Pubmed]
  5. Histochemistry of NADH diaphorase and gamma-glutamyltranspeptidase in rat bladder tumors. Vanderlaan, M., Fong, S., King, E.B. Carcinogenesis (1982) [Pubmed]
  6. The effect of nitric oxide synthase inhibition on quinolinic acid toxicity in the rat striatum. MacKenzie, G.M., Jenner, P., Marsden, C.D. Neuroscience (1995) [Pubmed]
  7. Manganese superoxide dismutase and reduced nicotinamide adenine dinucleotide diaphorase colocalize in the rat gut. Fang, S., Christensen, J. Gastroenterology (1995) [Pubmed]
  8. Nitric oxide production in experimental alcoholic liver disease in the rat: role in protection from injury. Nanji, A.A., Greenberg, S.S., Tahan, S.R., Fogt, F., Loscalzo, J., Sadrzadeh, S.M., Xie, J., Stamler, J.S. Gastroenterology (1995) [Pubmed]
  9. The localization of nitric oxide synthase in the rat eye and related cranial ganglia. Yamamoto, R., Bredt, D.S., Snyder, S.H., Stone, R.A. Neuroscience (1993) [Pubmed]
  10. Experimental hepatomas: dehydrogenation of reduced pyridine nucleotides by the D-T diaphorase. Schor, N.A., Morris, H.P. Proc. Soc. Exp. Biol. Med. (1976) [Pubmed]
  11. Changes in NADPH-diaphorase activity in the rat dorsal horn following an acute experimental myositis. Hoheisel, U., Reinert, A., Mense, S. Histochem. Cell Biol. (1995) [Pubmed]
  12. Effects of modulation of tissue activities of DT-diaphorase on the toxicity of 2,3-dimethyl-1,4-naphthoquinone to rats. Munday, R., Smith, B.L., Munday, C.M. Chem. Biol. Interact. (2001) [Pubmed]
  13. Heterogeneity of the rat NADH-cytochrome-b5-reductase transcripts resulting from multiple alternative first exons. Mota Vieira, L., Kaplan, J.C., Kahn, A., Leroux, A. Eur. J. Biochem. (1994) [Pubmed]
  14. Molecular cloning of a cDNA encoding rat NADH-cytochrome b5 reductase and the corresponding gene. Zenno, S., Hattori, M., Misumi, Y., Yubisui, T., Sakaki, Y. J. Biochem. (1990) [Pubmed]
  15. The reducing ability of iron chelates by NADH-cytochrome B5 reductase or cytochrome B5 responsible for NADH-supported lipid peroxidation. Miura, A., Tampo, Y., Yonaha, M. Biochem. Mol. Biol. Int. (1995) [Pubmed]
  16. Mechanism of rat liver microsomal stearyl-CoA desaturase. Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid. Enoch, H.G., Catalá, A., Strittmatter, P. J. Biol. Chem. (1976) [Pubmed]
  17. The NH2-terminal structures of human and rat liver microsomal NADH-cytochrome b5 reductases. Murakami, K., Yubisui, T., Takeshita, M., Miyata, T. J. Biochem. (1989) [Pubmed]
  18. Localization and biosynthesis of NADH-cytochrome b5 reductase, an integral membrane protein, in rat liver cells. I. Distribution of the enzyme activity in microsomes, mitochondria, and golgi complex. Borgese, N., Meldolesi, J. J. Cell Biol. (1980) [Pubmed]
  19. Rat erythrocyte NADH-cytochrome b5 reductase. Quantitation and comparison between the membrane-bound and soluble forms using an antibody against the rat liver enzyme. Borgese, N., Macconi, D., Parola, L., Pietrini, G. J. Biol. Chem. (1982) [Pubmed]
  20. The possible role of ATP-dependent proteolysis on the solubilization of methemoglobin reductase during reticulocyte maturation. Raw, I., DiFini, F. Biochem. Biophys. Res. Commun. (1983) [Pubmed]
  21. Bacterial synthesis of active rat stearyl-CoA desaturase lacking the 26-residue amino-terminal amino acid sequence. Strittmatter, P., Thiede, M.A., Hackett, C.S., Ozols, J. J. Biol. Chem. (1988) [Pubmed]
  22. Cytochrome c as an electron shuttle between the outer and inner mitochondrial membranes. Bernardi, P., Azzone, G.F. J. Biol. Chem. (1981) [Pubmed]
  23. Redox cycling of bleomycin-Fe(III) and DNA degradation by isolated NADH-cytochrome b5 reductase: involvement of cytochrome b5. Mahmutoglu, I., Kappus, H. Mol. Pharmacol. (1988) [Pubmed]
  24. Palmitoyl-CoA elongation in brain microsomes: dependence on cytochrome b5 and NADH-cytochrome b5 reductase. Takeshita, M., Tamura, M., Yoshida, S., Yubisui, T. J. Neurochem. (1985) [Pubmed]
  25. Evidence for a predominantly NADH-dependent O-dealkylating system in rat hepatic microsomes. Kuwahara, S., Mannering, G.J. Biochem. Pharmacol. (1985) [Pubmed]
  26. Vanadate-dependent NAD(P)H oxidation by microsomal enzymes. Reif, D.W., Coulombe, R.A., Aust, S.D. Arch. Biochem. Biophys. (1989) [Pubmed]
  27. Propylthiouracil, a selective inhibitor of NADH-cytochrome b5 reductase. Lee, E., Kariya, K. FEBS Lett. (1986) [Pubmed]
  28. Structural and functional analogs of CuZn superoxide dismutase inhibit rat brain nitric oxide synthase by interference with the reductase (diaphorase) domain. Mayer, B., Pfeiffer, S., Leopold, E., Müller, J., Weser, U., Schmidt, K. Neurosci. Lett. (1996) [Pubmed]
  29. DNA binding by 1-nitropyrene and 1,6-dinitropyrene in vitro and in vivo: effects of nitroreductase induction. Djurić, Z., Fifer, E.K., Yamazoe, Y., Beland, F.A. Carcinogenesis (1988) [Pubmed]
  30. Denaturation of cytochrome P-450 by indomethacin and other non-steroidal anti-inflammatory drugs: evidence for a surfactant mechanism and a selective effect of a p-chlorophenyl moiety. Falzon, M., Nielsch, A., Burke, M.D. Biochem. Pharmacol. (1986) [Pubmed]
  31. Distribution of enzymes involved in metabolism of polycyclic aromatic hydrocarbons among rat liver endomembranes and plasma membranes. Stasiecki, P., Oesch, F., Bruder, G., Jarasch, E.D., Franke, W.W. Eur. J. Cell Biol. (1980) [Pubmed]
  32. Rate of alteration of hepatic mixed-function oxidase system in rats fed different dietary fats. Ammouche, A., Dinh, L., Youyou, A., Clément, M., Bourre, J.M. Biochem. Cell Biol. (1993) [Pubmed]
  33. Enteric neuronal plasticity and a reduced number of interstitial cells of Cajal in hypertrophic rat ileum. Ekblad, E., Sjuve, R., Arner, A., Sundler, F. Gut (1998) [Pubmed]
  34. Renal nitric oxide production during the early phase of experimental diabetes mellitus. Keynan, S., Hirshberg, B., Levin-Iaina, N., Wexler, I.D., Dahan, R., Reinhartz, E., Ovadia, H., Wollman, Y., Chernihovskey, T., Iaina, A., Raz, I. Kidney Int. (2000) [Pubmed]
  35. Engineering and characterization of a NADPH-utilizing cytochrome b5 reductase. Marohnic, C.C., Bewley, M.C., Barber, M.J. Biochemistry (2003) [Pubmed]
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