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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Platelet-derived growth factor B-chain homodimer suppressing a convulsion of epilepsy model mouse El.

El mouse is a mutant which has epileptic convulsions after tossing-up stimulations and has a hippocampal dysfunction. Platelet-derived growth factor B-chain homodimer has been reported to be a trophic factor of hippocampal neurons. We found that a recombinant PDGF-BB suppressed the convulsions of El mice in a dose-dependent manner. Furthermore, thrombin-treated mice manifested no convulsions, but thrombin receptor activating peptide-treated ones had convulsions. These findings suggest that an abnormality in PDGF-BB release may make El mice susceptible to tonic-clonic convulsions.[1]

References

  1. Platelet-derived growth factor B-chain homodimer suppressing a convulsion of epilepsy model mouse El. Masuda, Y., Miura, N., Kawarada, Y., Kawagoe, M., Shimizu, T., Sugiyama, T., Hishikawa, Y. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
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