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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.

The gene cul-1 (formerly lin-19) is a negative regulator of the cell cycle in C. elegans. Null mutations cause hyperplasia of all tissues. cul-1 is required for developmentally programmed transitions from the G1 phase of the cell cycle to the GO phase or the apoptotic pathway. Moreover, the mutant phenotype suggests that G1-to-S phase progression is accelerated, overriding mechanisms for mitotic arrest and producing abnormally small cells. Significantly, diverse aspects of cell fate and differentiation are unaffected in cul-1 mutants. cul-1 represents a conserved family of genes, designated cullins, with at least five members in nematodes, six in humans, and three in budding yeast.[1]

References

  1. cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Kipreos, E.T., Lander, L.E., Wing, J.P., He, W.W., Hedgecock, E.M. Cell (1996) [Pubmed]
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