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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

G0 Phase

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Disease relevance of G0 Phase


High impact information on G0 Phase


Chemical compound and disease context of G0 Phase


Biological context of G0 Phase


Anatomical context of G0 Phase

  • The proportion of cells in the various phases of the cell cycle in the sigmoid epithelium was determined to be 81.6% +/- 2.15% (means +/- SE) in G1/G0 phase, 15.2% +/- 1.86% in S phase, and 3.2% +/- 0.62% in G2 + M phases [20].
  • A 20-residue synthetic peptide (termed 2.1) from a non-Ca2(+)-binding, disulfide-rich domain of SPARC also exhibited a dose-dependent inhibition of [3H]thymidine uptake in endothelial cells within 24 hr after release from G0 phase [21].
  • The hormone (1--10 ng/ml) causes a striking shift of the dose--response curve for the effect of serum on thymidine incorporation by cultures of 3T3 cells arrested in the G1/G0 phase of the cell cycle [22].
  • Mevalonic acid, which is essential for the growth of cells programmed to divide or stimulated to divide by mitogens, can by itself initiate cell replication in relatively inert G0 phase normal and neoplastic lymphocyte populations [23].
  • Absorption studies showed that BSF-1 in FS6 could be absorbed by unstimulated B cells, about 95% of which were at Go phase of the cell cycle, but not by thymocytes, and more importantly that alpha-Lyb-2 antibody blocked the absorption in an Lyb-2-specific manner, possibly by competing with BSF-1 [24].

Associations of G0 Phase with chemical compounds

  • The cross-linking pattern of 332C(TM6) with residues in TM10 and TM12 indicates that the drug-binding site undergoes dynamic and relatively large conformational changes, and that different residues are exposed to the drug-binding site during the resting phase, upon vanadate trapping and at the completion of the catalytic cycle [25].
  • HSCs (10(5) cells per well) in the G0 phase were added to these thymic lobes and cocultured at 37 degrees C in a 5% CO2/95% air incubator [26].
  • The cells were probed in resting phase and after coculture with saturating concentrations of IL-2, IL-7, and IL-15 [27].
  • In the present study, the effect of caffeine in quiescent (G0 phase) cells was investigated [28].
  • Yeast cells starved for inorganic phosphate on a glucose-containing medium arrest growth and enter the resting phase G0 [29].

Gene context of G0 Phase

  • The anti-proliferative effect of LY341495 was confirmed by measuring [methyl-3H]-thymidine incorporation in cultures arrested in G0 phase of the cell cycle and then stimulated to proliferate by the addition of 10% fetal calf serum or 100 ng/mL of epidermal growth factor (EGF) [30].
  • The transient increase of snoN transcript may represent a common entrance step of cells into the G0 phase where muscle differentiation is substantiated, considering that it was observed upon growth arrest of fibroblastic C3H10T1/2 cells and prior to the elevation of MCK in C2C12 but undetected when entry into G0 was blocked by b-FGF [31].
  • SPRR1B overexpression enhances entry of cells into the G0 phase of the cell cycle [32].
  • Growth arrest specific (gas) 1 gene product is expressed in non-transformed fibroblasts in response to stimuli driving cells into Go phase [33].
  • This was confirmed by double labelling studies, which showed that p21WAF1/CIP1 positive cells were in the G0 phase [34].

Analytical, diagnostic and therapeutic context of G0 Phase


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  10. Differential tumorigenicity of growth factor-dependent versus -independent CCL39 lung fibroblast lines in nude mice. Renwick, D.E., Franchi, A.J., Pouysségur, J.M., Lagarde, A.E. J. Natl. Cancer Inst. (1986) [Pubmed]
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  12. The plasma membrane NADH-diaphorase is active during selective phases of the cell cycle in mouse neuroblastoma cell line NB41A3. Its relation to cell growth and differentiation. Zurbriggen, R., Dreyer, J.L. Biochim. Biophys. Acta (1996) [Pubmed]
  13. Chronotoxicological effect of methyl mercury in rat submandibular gland. Immunohistochemical changes of r-EGF, S-100 protein and keratin. Battacharya, R.D., Sakamoto, F., Shrestha, P., Sumitomo, S., Mori, M. Acta Histochem. (1993) [Pubmed]
  14. 2-Chlorodeoxyadenosine: a potent antimetabolite with major activity in the treatment of indolent lymphoproliferative disorders. Saven, A., Piro, L.D. Hematology and cell therapy. (1996) [Pubmed]
  15. DNA alkylation and tumor induction in regenerating rat liver after cell cycle-related continuous N-nitrosodimethylamine infusion. Rabes, H.M., Kerler, R., Wilhelm, R. J. Natl. Cancer Inst. (1983) [Pubmed]
  16. Cdc6 protein causes premature entry into S phase in a mammalian cell-free system. Stoeber, K., Mills, A.D., Kubota, Y., Krude, T., Romanowski, P., Marheineke, K., Laskey, R.A., Williams, G.H. EMBO J. (1998) [Pubmed]
  17. Location of the cis-acting auxin-responsive region in the promoter of the par gene from tobacco mesophyll protoplasts. Takahashi, Y., Niwa, Y., Machida, Y., Nagata, T. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  18. Murine T-lymphocyte proliferation induced by interleukin 2 correlates with a transient increase in p56lck kinase activity and the tyrosine phosphorylation of a 97-kDa protein. Kim, Y.H., Buchholz, M.J., Nordin, A.A. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  19. Growth control in primary fetal rat liver cells in culture. Paul, D., Walter, S. J. Cell. Physiol. (1975) [Pubmed]
  20. Methods for the determination of epithelial cell kinetic parameters of human colonic epithelium isolated from surgical and biopsy specimens. Cheng, H., Bjerknes, M., Amar, J. Gastroenterology (1984) [Pubmed]
  21. The Ca2(+)-binding glycoprotein SPARC modulates cell cycle progression in bovine aortic endothelial cells. Funk, S.E., Sage, E.H. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  22. Vasopressin stimulation of mouse 3T3 cell growth. Rozengurt, E., Legg, A., Pettican, P. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  23. Mevalonic acid induces DNA synthesis in chronic lymphocytic leukemia cells. Larson, R.A., Yachnin, S. Blood (1984) [Pubmed]
  24. A role for Lyb-2 in B cell activation mediated by a B cell stimulatory factor. Yakura, H., Kawabata, I., Ashida, T., Shen, F.W., Katagiri, M. J. Immunol. (1986) [Pubmed]
  25. Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site. Loo, T.W., Clarke, D.M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  26. Analyses of T-cell differentiation from hemopoietic stem cells in the G0 phase by an in vitro method. Toki, J., Kumamoto, T., Ogata, H., Kawamura, M., Fukumoto, M., Cherry, n.u.l.l., Yamamoto, Y., Than, S., Inaba, M., Himeno, Y. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  27. Preassembly of interleukin 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: a fluorescence resonance energy transfer study. Damjanovich, S., Bene, L., Matkó, J., Alileche, A., Goldman, C.K., Sharrow, S., Waldmann, T.A. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  28. Caffeine inhibits cell proliferation by G0/G1 phase arrest in JB6 cells. Hashimoto, T., He, Z., Ma, W.Y., Schmid, P.C., Bode, A.M., Yang, C.S., Dong, Z. Cancer Res. (2004) [Pubmed]
  29. Inorganic phosphate is sensed by specific phosphate carriers and acts in concert with glucose as a nutrient signal for activation of the protein kinase A pathway in the yeast Saccharomyces cerevisiae. Giots, F., Donaton, M.C., Thevelein, J.M. Mol. Microbiol. (2003) [Pubmed]
  30. Pharmacological blockade of mGlu2/3 metabotropic glutamate receptors reduces cell proliferation in cultured human glioma cells. D'Onofrio, M., Arcella, A., Bruno, V., Ngomba, R.T., Battaglia, G., Lombari, V., Ragona, G., Calogero, A., Nicoletti, F. J. Neurochem. (2003) [Pubmed]
  31. A transient increase of snoN transcript by growth arrest upon serum deprivation and cell-to-cell contact. Mimura, N., Ichikawa, K., Asano, A., Nagase, T., Ishii, S. FEBS Lett. (1996) [Pubmed]
  32. SPRR1B overexpression enhances entry of cells into the G0 phase of the cell cycle. Tesfaigzi, Y., Wright, P.S., Belinsky, S.A. Am. J. Physiol. Lung Cell Mol. Physiol. (2003) [Pubmed]
  33. The growth suppressing gas1 product is a GPI-linked protein. Stebel, M., Vatta, P., Ruaro, M.E., Del Sal, G., Parton, R.G., Schneider, C. FEBS Lett. (2000) [Pubmed]
  34. Expression of p21WAF1/CIP1 in fetal and adult tissues: simultaneous analysis with Ki67 and p53. Mateo, M.S., Saez, A.I., Sanchez-Beato, M., Garcia, P., Sanchez-Verde, L., Martinez, J.C., Orradre, J.L., Piris, M.A. J. Clin. Pathol. (1997) [Pubmed]
  35. Antiproliferative effect of 1alpha,25-dihydroxyvitamin D3 in human prostate cancer cell line LNCaP involves reduction of cyclin-dependent kinase 2 activity and persistent G1 accumulation. Zhuang, S.H., Burnstein, K.L. Endocrinology (1998) [Pubmed]
  36. Clusterin (SGP-2) gene expression is cell cycle dependent in normal human dermal fibroblasts. Bettuzzi, S., Astancolle, S., Guidetti, G., Moretti, M., Tiozzo, R., Corti, A. FEBS Lett. (1999) [Pubmed]
  37. A new screening system for proliferation-independent anti-cancer agents. Horiatis, D., Wang, Q., Pinski, J. Cancer Lett. (2004) [Pubmed]
  38. cAMP and PMA enhance the effects of IGF-I in the proliferation of endometrial adenocarcinoma cell line HEC-1-A by acting at the G1 phase of the cell cycle. Talavera, F., Bergman, C., Pearl, M.L., Connor, P., Roberts, J.A., Menon, K.M. Cell Prolif. (1995) [Pubmed]
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