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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

G0 Phase

 
 
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Disease relevance of G0 Phase

 

High impact information on G0 Phase

 

Chemical compound and disease context of G0 Phase

 

Biological context of G0 Phase

 

Anatomical context of G0 Phase

  • The proportion of cells in the various phases of the cell cycle in the sigmoid epithelium was determined to be 81.6% +/- 2.15% (means +/- SE) in G1/G0 phase, 15.2% +/- 1.86% in S phase, and 3.2% +/- 0.62% in G2 + M phases [20].
  • A 20-residue synthetic peptide (termed 2.1) from a non-Ca2(+)-binding, disulfide-rich domain of SPARC also exhibited a dose-dependent inhibition of [3H]thymidine uptake in endothelial cells within 24 hr after release from G0 phase [21].
  • The hormone (1--10 ng/ml) causes a striking shift of the dose--response curve for the effect of serum on thymidine incorporation by cultures of 3T3 cells arrested in the G1/G0 phase of the cell cycle [22].
  • Mevalonic acid, which is essential for the growth of cells programmed to divide or stimulated to divide by mitogens, can by itself initiate cell replication in relatively inert G0 phase normal and neoplastic lymphocyte populations [23].
  • Absorption studies showed that BSF-1 in FS6 could be absorbed by unstimulated B cells, about 95% of which were at Go phase of the cell cycle, but not by thymocytes, and more importantly that alpha-Lyb-2 antibody blocked the absorption in an Lyb-2-specific manner, possibly by competing with BSF-1 [24].
 

Associations of G0 Phase with chemical compounds

  • The cross-linking pattern of 332C(TM6) with residues in TM10 and TM12 indicates that the drug-binding site undergoes dynamic and relatively large conformational changes, and that different residues are exposed to the drug-binding site during the resting phase, upon vanadate trapping and at the completion of the catalytic cycle [25].
  • HSCs (10(5) cells per well) in the G0 phase were added to these thymic lobes and cocultured at 37 degrees C in a 5% CO2/95% air incubator [26].
  • The cells were probed in resting phase and after coculture with saturating concentrations of IL-2, IL-7, and IL-15 [27].
  • In the present study, the effect of caffeine in quiescent (G0 phase) cells was investigated [28].
  • Yeast cells starved for inorganic phosphate on a glucose-containing medium arrest growth and enter the resting phase G0 [29].
 

Gene context of G0 Phase

  • The anti-proliferative effect of LY341495 was confirmed by measuring [methyl-3H]-thymidine incorporation in cultures arrested in G0 phase of the cell cycle and then stimulated to proliferate by the addition of 10% fetal calf serum or 100 ng/mL of epidermal growth factor (EGF) [30].
  • The transient increase of snoN transcript may represent a common entrance step of cells into the G0 phase where muscle differentiation is substantiated, considering that it was observed upon growth arrest of fibroblastic C3H10T1/2 cells and prior to the elevation of MCK in C2C12 but undetected when entry into G0 was blocked by b-FGF [31].
  • SPRR1B overexpression enhances entry of cells into the G0 phase of the cell cycle [32].
  • Growth arrest specific (gas) 1 gene product is expressed in non-transformed fibroblasts in response to stimuli driving cells into Go phase [33].
  • This was confirmed by double labelling studies, which showed that p21WAF1/CIP1 positive cells were in the G0 phase [34].
 

Analytical, diagnostic and therapeutic context of G0 Phase

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