The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Immunotoxic effects of copper and cadmium in the sea bass Dicentrarchus labrax.

Two phagocytes-mediated activities of the sea bass Dicentrarchus labrax were examined after exposure to sublethal concentrations of copper and cadmium: (a) phagocytosis (measured by phagocytotic index), and (b) the production of reactive oxygen intermediates (luminol-dependent chemiluminescence) in response to bacteria Aeromonas salmonicida. In vivo exposure for 48 h to each metal separately by intraperitoneal injection did not affect the quantity of phagocytes of pronephros and their viability but inhibited, in dose-dependent manner, phagocytosis and chemiluminescence of these cells. The half-inhibition value was 250 micrograms kg-1 for copper and 1 mg kg-1 for cadmium. In vitro exposure to copper for 30 min had the same immunomodulatory effect on macrophage chemiluminescence as that observed in vivo, whereas treatment with cadmium under the same conditions had a dose-dependent effect opposite to that observed in vivo. Assessment of these two macrophage-mediated functions could therefore be used as early bioindicators of the marine pollution.[1]


  1. Immunotoxic effects of copper and cadmium in the sea bass Dicentrarchus labrax. Bennani, N., Schmid-Alliana, A., Lafaurie, M. Immunopharmacology and immunotoxicology. (1996) [Pubmed]
WikiGenes - Universities