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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Evaluation of pain following electrocautery tubal ligation and effect of intraoperative fentanyl.

STUDY OBJECTIVE: To evaluate pain following laparoscopic tubal sterilization (LTS) and the effects of supplemental intraoperative fentanyl. DESIGN: Open evaluation of pain intensity and opioid requirements with double-blind, randomized evaluation of intraoperative fentanyl. SETTING: Outpatient center of a university-affiliated teaching hospital. PATIENTS: 44 ASA status I patients who underwent LTS by electrocautery. INTERVENTIONS: Patients received either intravenous fentanyl (F) 1 microgram/kg or saline ( S) at induction. MEASUREMENTS AND MAIN RESULTS: Pain intensity was measured with patient assessments of visual analog scales (VAS) and cumulative opioid requirements. The group that received intraoperative fentanyl received 70.2 +/- 3.7 micrograms at induction. VAS on postanesthesia care unit arrival was 4.9 +/- 0.5 (F) and 5.9 +/- 0.5 ( S) (means +/- SEM). VAS after one hour was 2.1 +/- 0.2 in both groups. During that hour, the F group consumed 107.5 +/- 14.7 micrograms and the S group consumed 140.5 +/- 15.7 micrograms fentanyl. The range of fentanyl consumed by each group in the postoperative period was 0 to 250 micrograms. There were no statistically significant differences between the F and S groups. CONCLUSIONS: Pain following LTS by electrocautery is of significant magnitude and may require relatively large doses of opioids for adequate management. Supplemental intraoperative fentanyl 1 microgram/kg did not produce a clinically significant reduction in either pain scores or opioid requirements.[1]

References

  1. Evaluation of pain following electrocautery tubal ligation and effect of intraoperative fentanyl. Curry, C.S., Darby, J.R., Janssen, B.R. Journal of clinical anesthesia. (1996) [Pubmed]
 
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