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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Antiepileptic effects of acidic fibroblast growth factor examined in kainic acid-mediated seizures in the rat.

The possibility that exogenous recombinant human acidic fibroblast growth factor (rhaFGF) may have anticonvulsant properties was investigated in a model of temporal lobe epilepsy in awake rats. We found that after intraperitoneal injection of rhaFGF in kainic acid-treated rats, tonic-clonic convulsions and mortality were decreased by 74% and 77%, respectively. These results are consistent with previous studies showing a neuroprotective effect of FGF against insults to the brain and support a possible therapeutic role for FGF in the treatment of excitotoxic processes.[1]


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