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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Permeability of the liver cell membrane to quinolinate.

Quinolinate was taken up by both rat and guinea-pig liver cells. Equilibrium was reached after approx. 20 min with rat cells, but guinea-pig cells had not achieved a steady state after 60 min. There was no evidence to suggest that quinolinate is rapidly metabolized by either species. The concentrations of quinolinate attained in rat and guinea-pig cells after short periods of incubation with 0.5 mM-quinolinate did not inhibit gluconeogenesis. These results raise further doubts as to the mechanism of quinolinate action in liver.[1]


  1. Permeability of the liver cell membrane to quinolinate. Elliott, K.R., Pogson, C.I., Smith, S.A. Biochem. J. (1977) [Pubmed]
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