Aup1, a novel gene on mouse chromosome 6 and human chromosome 2p13.
We have cloned a novel mouse cDNA, Aup1, encoding a predicted protein of 410 amino acid residues. The 1.5-kb Aup1 transcript is ubiquitously expressed in mouse tissues. An evolutionary relationship to the Caenorhabditis elegans predicted protein F44b9.5 is indicated by the 35% identity and 53% conservation of the amino acid sequences. Nineteen related human ESTs spanning 80% of the protein have also been identified, with a predicted amino acid sequence identity of 86% between the human and the mouse proteins. The gene has been mapped to a conserved linkage group on human chromosome 2p13 and mouse Chromosome 6. Aup1 was eliminated as a candidate gene for two closely linked disorders, human LGMD2B and mouse mnd2.[1]References
- Aup1, a novel gene on mouse chromosome 6 and human chromosome 2p13. Jang, W., Weber, J.S., Bashir, R., Bushby, K., Meisler, M.H. Genomics (1996) [Pubmed]
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