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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Pressor action of angiotensin I at the ventrolateral medulla: effect of selective angiotensin blockade.

In this study we explored the possibility that angiotensin-(1-7) (Ang-(1-7)) is involved in the control of blood pressure at the rostral ventrolateral medulla (RVLM) by determining the effect of angiotensin antagonists (DuP 753 and A-779) and the effect of the angiotensin converting enzyme inhibitor, ramiprilat on the pressor action produced by angiotensin I (Ang I). The pressor effect produced by bilateral microinjection of Ang I into the RVLM of anesthetized rats was not significantly altered by DuP 753 or by the ACE inhibitor ramiprilat. Conversely, the Ang-(1-7) antagonist, A-779, reduced significantly the pressor effect produced by Ang I. These data suggest that in our experimental condition Ang I was preferentially converted to Ang-(1-7) at RVLM, or that Ang I and/or one of its fragments acts through a receptor blocked by A-779.[1]

References

  1. Pressor action of angiotensin I at the ventrolateral medulla: effect of selective angiotensin blockade. Lima, D.X., Fontes, M.A., Oliveira, R.C., Campagnole-Santos, M.J., Khosla, M.C., Santos, R.A. Immunopharmacology (1996) [Pubmed]
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