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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Genetic diversity of flagellins of Pseudomonas aeruginosa.

Physical genome analysis of the virulence-associated fliC locus in 20 Pseudomonas aeruginosa strains by mapping and sequencing revealed groups of heterologous a-type (1164 bp; 1185 bp) and highly conserved b-type (1467 bp) flagellin genes. Whereas only two synonymous nucleotide substitutions were detected in eight b-type fliC sequences, the 12 a-type sequences exhibited 57 nucleotide substitutions, of which 39 occurred within a variable central region. Although a-type and b-type flagellins differ by 35% in their primary structure, they share strong homology in their predicted features, implying that the polymorphic proteins fold into similar structures during polymerization of the flagella.[1]


  1. Genetic diversity of flagellins of Pseudomonas aeruginosa. Spangenberg, C., Heuer, T., Bürger, C., Tümmler, B. FEBS Lett. (1996) [Pubmed]
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