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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

SNAP-25 is present on chromaffin granules and acts as a SNAP receptor.

SNAP-25 is located on the plasma membrane and essential for exocytosis of neurotransmitters. It was suggested that SNAP-25 and syntaxin 1 via the interaction with VAMP-2 located on synaptic vesicles mediate the docking of the vesicles with the plasma membrane. In the present study, by means of biochemical and morphological analyses, we showed that SNAP-25 is present on chromaffin granules as well as on the plasma membrane. Reconstitution and immunoprecipitation analyses revealed that SNAP-25 on chromaffin granules has essentially the same properties as does SNAP-25 on the plasma membrane.[1]


  1. SNAP-25 is present on chromaffin granules and acts as a SNAP receptor. Tagaya, M., Genma, T., Yamamoto, A., Kozaki, S., Mizushima, S. FEBS Lett. (1996) [Pubmed]
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