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Koike, G. et al.

Koike, Van Vooren, Shiozawa, Galli, Li, Glaser, Balasubramanyam, Brown, Luthman, Szpirer, MacDonald, Jacob,

Genetic mapping and chromosome localization of the rat mitochondrial glycerol-3-phosphate dehydrogenase gene, a candidate for non-insulin-dependent diabetes mellitus.

The mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase (mtGPD) plays an important role in the regulation of insulin secretion and has been postulated as a candidate responsible for the pathogenesis of non-insulin-dependent diabetes mellitus ( NIDDM) in humans as well as in rodent models of NIDDM. Recent molecular genetic studies of the Goto-Kakizaki (GK) rat model of NIDDM have identified loci linked to NIDDM. To elucidate whether rat mtGPD might play a role in the pathogenesis of NIDDM, the rat mtGPD gene (Gpd2) was cloned, and a genetic marker for Gpd2 was developed. The gene mapped to the region of rat chromosome 3 that contains a region linked to NIDDM in the GK rat. Fluorescence in situ hybridization was also carried out to verify the map position.[1]

References

Genetic mapping and chromosome localization of the rat mitochondrial glycerol-3-phosphate dehydrogenase gene, a candidate for non-insulin-dependent diabetes mellitus. Koike, G., Van Vooren, P., Shiozawa, M., Galli, J., Li, L.S., Glaser, A., Balasubramanyam, A., Brown, L.J., Luthman, H., Szpirer, C., MacDonald, M.J., Jacob, H.J. Genomics (1996) [Pubmed]

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