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Gene Review

Edpm3  -  Estrogen-dependent pituitary mass QTL 3

Rattus norvegicus

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Disease relevance of Edpm3


High impact information on Edpm3

  • In four of the lines integration of ras was accompanied by deletion of the p arm of chromosome 3 or its possible translocation to chromosome 12 [6].
  • HR after NaCl loading but not at baseline was significantly linked in a recessive fashion to a locus on chromosome 3: in animals homozygous for the SHRSP(HD) allele, HR was 414+/-49 compared with 383+/-44 bpm in heterozygotes and WKY homozygotes (F(210,1)=19.7, P=1.4x10(-5), lod score=5.9) [7].
  • B-myc mapped to rat chromosome 3 [8].
  • The ras-transfected cell line selected for growth in soft agar, WBras, had acquired a loss of chromosome 3 (12%) or 3p (34%), a trisomy of chromosome 1, as well as the chromosome Y loss [9].
  • Previous studies on F2 rats from a cross of stroke-prone SHR and WKY have shown a suggestive level of linkage between elevated blood pressure and the KAT-1 locus on chromosome 3 [10].

Chemical compound and disease context of Edpm3


Biological context of Edpm3

  • Using the Mapmaker/QTL computer package, we identified a significant QTL on chromosome 3 with a log10 likelihood (LOD) score of 4.8, which accounted for 16.5% of the total variance of LV weight [12].
  • These analyses revealed several suggestive quantitative trait loci (QTL), some of which were, indeed, significant for both newborn and adult relative kidney weight (such as, D3Mit9 on rat chromosome 3; r = -0.50, P < 0.01; r = -0.47, P < 0.01; respectively) [13].
  • RESULTS: A single AT1 gene (AT1) was detected in the human genome, and was assigned to chromosome 3, whereas two non-syntenic genes were detected in the rat genome, corresponding to the previously identified A and B subtypes [14].
  • Normalization using Actb most appropriately explained the expression levels in a congenic strain for chromosome 3. eQTL analysis with precise measurement of expression levels and appropriate normalization was shown to be effective for mapping loci that control gene expression in vivo [15].
  • Finally, analysis of somatic cell hybrids by PCR and fluorescence in situ hybridization to metaphase chromosomes has localized the mouse CGT gene to chromosome 3, bands E3-F1 [16].

Anatomical context of Edpm3


Associations of Edpm3 with chemical compounds

  • Localization of the vasopressin gene to rat chromosome 3 [21].
  • On chromosome 3, the maximum lod score in the full sample was 2.7 with saccharin consumption [22].
  • Observations of the remarkable phenotypic similarity that exists between children with deletion of bands p25-pter of chromosome 3 and taurine-deficient kits led us to hypothesize that deletion of the renal taurine transporter gene (TauT) might contribute to some features of the 3p-syndrome [23].

Other interactions of Edpm3


Analytical, diagnostic and therapeutic context of Edpm3


  1. Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3. Dammann, R., Li, C., Yoon, J.H., Chin, P.L., Bates, S., Pfeifer, G.P. Nat. Genet. (2000) [Pubmed]
  2. The gene from the short arm of chromosome 3, at D3F15S2, frequently deleted in renal cell carcinoma, encodes acylpeptide hydrolase. Erlandsson, R., Boldog, F., Persson, B., Zabarovsky, E.R., Allikmets, R.L., Sümegi, J., Klein, G., Jörnvall, H. Oncogene (1991) [Pubmed]
  3. Structure and function of the cardiac sodium channels. Balser, J.R. Cardiovasc. Res. (1999) [Pubmed]
  4. Sex-specific and sex-independent quantitative trait loci for facets of the metabolic syndrome in WOKW rats. Klöting, I., Kovács, P., van den Brandt, J. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  5. In search of genes causing spontaneous hypertension. Nara, Y., Ikeda, K., Matsumoto, C., Nabika, T., Sawamura, M., Yamori, Y. Clin. Exp. Pharmacol. Physiol. (1995) [Pubmed]
  6. Site-specific integration of H-ras in transformed rat embryo cells. McKenna, W.G., Nakahara, K., Muschel, R.J. Science (1988) [Pubmed]
  7. Evidence for primary genetic determination of heart rate regulation: chromosomal mapping of a genetic locus in the rat. Kreutz, R., Struk, B., Stock, P., Hübner, N., Ganten, D., Lindpaintner, K. Circulation (1997) [Pubmed]
  8. Structure and expression of B-myc, a new member of the myc gene family. Ingvarsson, S., Asker, C., Axelson, H., Klein, G., Sümegi, J. Mol. Cell. Biol. (1988) [Pubmed]
  9. Cytogenetic analysis of three rat liver epithelial cell lines (WBneo, WBHa-ras, and WBrasIIa) and correlation of an early chromosomal alteration with insulin-like growth factor II expression. Sargent, L., Dragan, Y.P., Babcock, K., Wiley, J., Klaunig, J., Pitot, H.C. Cancer Res. (1996) [Pubmed]
  10. A missense mutation in kynurenine aminotransferase-1 in spontaneously hypertensive rats. Kwok, J.B., Kapoor, R., Gotoda, T., Iwamoto, Y., Iizuka, Y., Yamada, N., Isaacs, K.E., Kushwaha, V.V., Church, W.B., Schofield, P.R., Kapoor, V. J. Biol. Chem. (2002) [Pubmed]
  11. Genetic dissection of the syndrome X in the rat. Kovács, P., van den Brandt, J., Klöting, I. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  12. Genetic determination of cardiac mass in normotensive rats: results from an F344xWKY cross. Sebkhi, A., Zhao, L., Lu, L., Haley, C.S., Nunez, D.J., Wilkins, M.R. Hypertension (1999) [Pubmed]
  13. Newborn and adult recombinant inbred strains: a tool to search for genetic determinants of target organ damage in hypertension. Hamet, P., Pausova, Z., Dumas, P., Sun, Y.L., Tremblay, J., Pravenec, M., Kunes, J., Krenova, D., Kren, V. Kidney Int. (1998) [Pubmed]
  14. Chromosomal assignment of human and rat hypertension candidate genes: type 1 angiotensin II receptor genes and the SA gene. Szpirer, C., Rivière, M., Szpirer, J., Levan, G., Guo, D.F., Iwai, N., Inagami, T. J. Hypertens. (1993) [Pubmed]
  15. Expression quantitative trait loci analysis of 13 genes in the rat prostate. Yamashita, S., Wakazono, K., Nomoto, T., Tsujino, Y., Kuramoto, T., Ushijima, T. Genetics (2005) [Pubmed]
  16. Molecular cloning, chromosomal mapping, and characterization of the mouse UDP-galactose:ceramide galactosyltransferase gene. Coetzee, T., Li, X., Fujita, N., Marcus, J., Suzuki, K., Francke, U., Popko, B. Genomics (1996) [Pubmed]
  17. Chromosomal location of the genes encoding complement components C5 and factor H in the mouse. D'Eustachio, P., Kristensen, T., Wetsel, R.A., Riblet, R., Taylor, B.A., Tack, B.F. J. Immunol. (1986) [Pubmed]
  18. Specific chromosome change associated with acquisition in vivo of tumorigenicity in carcinogen-induced rat urinary bladder carcinoma cells. Debiec-Rychter, M., Azuma, M., Zukowski, K., Oyasu, R., Wang, C.Y. Genes Chromosomes Cancer (1991) [Pubmed]
  19. Cosegregation of the endothelin-3 locus with blood pressure and relative heart weight in inbred Dahl rats. Cicila, G.T., Rapp, J.P., Bloch, K.D., Kurtz, T.W., Pravenec, M., Kren, V., Hong, C.C., Quertermous, T., Ng, S.C. J. Hypertens. (1994) [Pubmed]
  20. The myelin vacuolation (mv) rat with a null mutation in the attractin gene. Kuwamura, M., Maeda, M., Kuramoto, T., Kitada, K., Kanehara, T., Moriyama, M., Nakane, Y., Yamate, J., Ushijima, T., Kotani, T., Serikawa, T. Lab. Invest. (2002) [Pubmed]
  21. Localization of the vasopressin gene to rat chromosome 3. Khegay, I.I. Mamm. Genome (1996) [Pubmed]
  22. Mapping of QTL influencing saccharin consumption in the selectively bred alcohol-preferring and -nonpreferring rat lines. Foroud, T., Bice, P., Castelluccio, P., Bo, R., Ritchotte, A., Stewart, R., Lumeng, L., Li, T.K., Carr, L. Behav. Genet. (2002) [Pubmed]
  23. The taurine transporter gene and its role in renal development. Han, X., Budreau, A.M., Chesney, R.W. Amino Acids (2000) [Pubmed]
  24. Quantitative trait loci for estrogen-dependent pituitary tumor growth in the rat. Wendell, D.L., Gorski, J. Mamm. Genome (1997) [Pubmed]
  25. Localization of the rat stimulatory G-protein alpha subunit (GNPAS) gene to rat chromosome 3 by linkage analysis. Kato, N., Bihoreau, M., Lathrop, G.M., Rapp, J.P. Mamm. Genome (1996) [Pubmed]
  26. Kynureninase is a novel candidate gene for hypertension in spontaneously hypertensive rats. Mizutani, K., Sugimoto, K., Okuda, T., Katsuya, T., Miyata, T., Tanabe, T., Higaki, J., Ogihara, T., Yamori, Y., Tsujita, Y., Tago, N., Iwai, N. Hypertens. Res. (2002) [Pubmed]
  27. Genetic mapping of genes regulating the thymus size in back-cross rats between the laboratory BUF/Mna strain and the MITE strain derived from the wild rat, Rattus norvegicus. Sharma, N., Ohyabu, A., Murakumo, Y., Takahashi, M., Saito, M., Amo, H., Murayama, S., Ohno, K., Oda, S., Matsuyama, M. Pathol. Int. (1997) [Pubmed]
  28. Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice. Gordon, E.J., Wicker, L.S., Peterson, L.B., Serreze, D.V., Markees, T.G., Shultz, L.D., Rossini, A.A., Greiner, D.L., Mordes, J.P. Diabetes (2005) [Pubmed]
  29. cDNA cloning and chromosomal mapping of a novel human GAP (GAP1M), a GTPase-activating protein of Ras. Li, S., Satoh, H., Watanabe, T., Nakamura, S., Hattori, S. Genomics (1996) [Pubmed]
  30. Linkage mapping of the Na-K-2Cl cotransporter gene (Slc12a1) to rat chromosome 3. Wang, J., Pravenec, M., Kren, V., Kurtz, T.W. Mamm. Genome (1997) [Pubmed]
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