The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Effect of aortic baroreceptor deafferentation on plasma vasopressin and oxytocin in the conscious rat.

Experiments were done in conscious, unrestrained rats to investigate the effects of selective aortic baroreceptor deafferentation (ABD) on circulating levels of the neurohypophysial hormones arginine vasopressin (AVP) and oxytocin (OXY). Plasma concentration of AVP and OXY were measured by radioimmunoassay before and 1-13 days after cutting the aortic depressor nerves, bilaterally. Arterial pressure was significantly elevated by approximately 12-39 mmHg above control levels after ABD. On day one after ABD, plasma AVP increased from control levels of 3.21 +/- 1.56 pg/ml to 8.29 +/- 4.66 pg/ml (258%) and plasma OXY increased from 2.53 +/- 4.24 pg/ml to 8.16 +/- 1.49 pg/ml (323%). However, by the third day after ABD, plasma AVP and OXY levels had returned to pre-ABD control levels. On days 8 and 13 after ABD, AVP levels were elevated again by approximately 2- and 9-fold, respectively, whereas the OXY levels remained at control levels. These data suggest that in the awake rat, the release of AVP and OXY is modulated differentially after ABD and that the increased circulating levels of AVP may be one of the mechanisms that contributes to the elevated arterial pressure in neurogenic hypertension.[1]


WikiGenes - Universities