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MeSH Review


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Disease relevance of Pressoreceptors


Psychiatry related information on Pressoreceptors

  • Effects of PRES baroreceptor stimulation on thermal and mechanical pain threshold in borderline hypertensives and normotensives [6].
  • A group (N = 8) of restrained, baroreceptor denervated rats and a sham-operated-control group (n = 8) received discriminated classical conditioning consisting of 30 reinforced trials in which a CS+ was paired with an electric shock US and 30 non-reinforced trials in which a different CS (CS-) was presented alone [7].
  • In a sample of 96 healthy, normotensive men and women, amount of pain-reduction produced by baroreceptor stimulation predicted an increase in resting BP 20 months later: the increase was proportional to self-assessed daily life stress [8].

High impact information on Pressoreceptors


Chemical compound and disease context of Pressoreceptors


Biological context of Pressoreceptors


Anatomical context of Pressoreceptors


Associations of Pressoreceptors with chemical compounds

  • Animal studies suggest that cocaine not only blocks norepinephrine reuptake peripherally but also inhibits the baroreceptors, thereby reflexively increasing sympathetic nerve discharge [26].
  • This appears to be due to decreased formation of prostacyclin rather than decreased sensitivity of the baroreceptors to prostacyclin [27].
  • Inhibition of the endogenous formation of prostanoids with intrasinus administration of indomethacin (50 microM) decreased baroreceptor activity in normotensive (P less than 0.05) but not in hypertensive rabbits over a wide range of pressures [27].
  • In five dogs with vagi intact, carotid sinuses isolated and held at a pressure of 100 mmHg, and aortic baroreceptors denervated, administration of lidocaine (2.5 mg/kg followed by 200 micrograms/kg per min) decreased renal nerve activity to 71 +/- 8% of control [28].
  • PE increased mean arterial pressure (MAP) by 13 +/- 2 mmHg (mean +/- SEM; n = 10) and thus stimulated both carotid and aortic baroreceptors [19].

Gene context of Pressoreceptors


Analytical, diagnostic and therapeutic context of Pressoreceptors


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  2. Blockade of brain 'ouabain' prevents the impairment of baroreflexes in rats after myocardial infarction. Huang, B.S., Yuan, B., Leenen, F.H. Circulation (1997) [Pubmed]
  3. Comparison between noninvasive indices of baroreceptor sensitivity and the phenylephrine method in post-myocardial infarction patients. Pitzalis, M.V., Mastropasqua, F., Passantino, A., Massari, F., Ligurgo, L., Forleo, C., Balducci, C., Lombardi, F., Rizzon, P. Circulation (1998) [Pubmed]
  4. Blood pressure response to central and/or peripheral inhibition of phenylethanolamine N-methyltransferase in normotensive and hypertensive rats. Black, J., Waeber, B., Bresnahan, M.R., Gavras, I., Gavras, H. Circ. Res. (1981) [Pubmed]
  5. Relative roles of cardiac and arterial baroreceptors in vasopressin regulation during hemorrhage in conscious dogs. Shen, Y.T., Cowley, A.W., Vatner, S.F. Circ. Res. (1991) [Pubmed]
  6. Effects of PRES baroreceptor stimulation on thermal and mechanical pain threshold in borderline hypertensives and normotensives. Rau, H., Brody, S., Larbig, W., Pauli, P., Vöhringer, M., Harsch, B., Kröling, P., Birbaumer, N. Psychophysiology. (1994) [Pubmed]
  7. Baroreceptor involvement in classically conditioned heart rate responses of restrained rats. Hatton, D.C., Foutz, S.R., Fitzgerald, R.D. Physiol. Behav. (1984) [Pubmed]
  8. Sensory effects of baroreceptor activation and perceived stress together predict long-term blood pressure elevations. Elbert, T., Dworkin, B.R., Rau, H., Pauli, P., Birbaumer, N., Droste, C., Brunia, C.H. International journal of behavioral medicine. (1994) [Pubmed]
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  10. Evidence for L-glutamate as the neurotransmitter of baroreceptor afferent nerve fibers. Talman, W.T., Perrone, M.H., Reis, D.J. Science (1980) [Pubmed]
  11. The neuroendocrinology of thirst and salt appetite: visceral sensory signals and mechanisms of central integration. Johnson, A.K., Thunhorst, R.L. Frontiers in neuroendocrinology. (1997) [Pubmed]
  12. Baroreceptor regulation of vasopressin and renin secretion: low-pressure versus high-pressure receptors. Thrasher, T.N. Frontiers in neuroendocrinology. (1994) [Pubmed]
  13. Cardiovascular and neurohumoral postural responses and baroreceptor abnormalities during a course of adjunctive vasodilator therapy with felodipine for congestive heart failure. Kassis, E., Amtorp, O. Circulation (1987) [Pubmed]
  14. Low-pressure-sensitive baroreceptor fibers recorded from rabbit carotid sinus nerves. Qu, L., Stuesse, S.L. Circ. Res. (1991) [Pubmed]
  15. Clonidine raises blood pressure in severe idiopathic orthostatic hypotension. Robertson, D., Goldberg, M.R., Hollister, A.S., Wade, D., Robertson, R.M. Am. J. Med. (1983) [Pubmed]
  16. Adenosine: potential modulator for vasovagal syncope. Shen, W.K., Hammill, S.C., Munger, T.M., Stanton, M.S., Packer, D.L., Osborn, M.J., Wood, D.L., Bailey, K.R., Low, P.A., Gersh, B.J. J. Am. Coll. Cardiol. (1996) [Pubmed]
  17. Ephedrine increases ventricular arrhythmias in conscious dogs after myocardial infarction. Adamson, P.B., Suarez, J., Ellis, E., Kanaly, T., Vanoli, E. J. Am. Coll. Cardiol. (2004) [Pubmed]
  18. Paradoxical withdrawal of reflex vasoconstriction as a cause of hemodialysis-induced hypotension. Converse, R.L., Jacobsen, T.N., Jost, C.M., Toto, R.D., Grayburn, P.A., Obregon, T.M., Fouad-Tarazi, F., Victor, R.G. J. Clin. Invest. (1992) [Pubmed]
  19. Relative contribution of aortic and carotid baroreflexes to heart rate control in man during steady state and dynamic increases in arterial pressure. Ferguson, D.W., Abboud, F.M., Mark, A.L. J. Clin. Invest. (1985) [Pubmed]
  20. Corticotropin-releasing hormone causes antidiuresis and antinatriuresis by stimulating vasopressin and inhibiting atrial natriuretic peptide release in male rats. Gutkowska, J., Jankowski, M., Mukaddam-Daher, S., McCann, S.M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  21. Vasopressin and arterial pressure regulation. Special lecture. Cowley, A.W., Liard, J.F. Hypertension (1988) [Pubmed]
  22. Oxytocin mediates atrial natriuretic peptide release and natriuresis after volume expansion in the rat. Haanwinckel, M.A., Elias, L.K., Favaretto, A.L., Gutkowska, J., McCann, S.M., Antunes-Rodrigues, J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  23. Prostaglandins contribute to activation of baroreceptors in rabbits. Possible paracrine influence of endothelium. Chen, H.I., Chapleau, M.W., McDowell, T.S., Abboud, F.M. Circ. Res. (1990) [Pubmed]
  24. A direct excitatory action of catecholamines on rat aortic baroreceptors in vitro. Goldman, W.F., Saum, W.R. Circ. Res. (1984) [Pubmed]
  25. Metabotropic glutamate receptors mediate excitatory transmission in the nucleus of the solitary tract. Glaum, S.R., Miller, R.J. J. Neurosci. (1992) [Pubmed]
  26. Effects of intranasal cocaine on sympathetic nerve discharge in humans. Jacobsen, T.N., Grayburn, P.A., Snyder, R.W., Hansen, J., Chavoshan, B., Landau, C., Lange, R.A., Hillis, L.D., Victor, R.G. J. Clin. Invest. (1997) [Pubmed]
  27. Mechanism of decreased baroreceptor activity in chronic hypertensive rabbits. Role of endogenous prostanoids. Xie, P.L., Chapleau, M.W., McDowell, T.S., Hajduczok, G., Abboud, F.M. J. Clin. Invest. (1990) [Pubmed]
  28. Inhibition of cardiac sympathetic nerve activity during intravenous administration of lidocaine. Miller, B.D., Thames, M.D., Mark, A.L. J. Clin. Invest. (1983) [Pubmed]
  29. Disruption of the Hoxa3 homeobox gene results in anomalies of the carotid artery system and the arterial baroreceptors. Kameda, Y., Watari-Goshima, N., Nishimaki, T., Chisaka, O. Cell Tissue Res. (2003) [Pubmed]
  30. Angiotensin peptides as neurotransmitters/neuromodulators in the dorsomedial medulla. Diz, D.I., Jessup, J.A., Westwood, B.M., Bosch, S.M., Vinsant, S., Gallagher, P.E., Averill, D.B. Clin. Exp. Pharmacol. Physiol. (2002) [Pubmed]
  31. Recent advances in the understanding of water metabolism in heart failure. Schrier, R.W., Martin, P.Y. Adv. Exp. Med. Biol. (1998) [Pubmed]
  32. Renin stimulating properties of parathyroid hormone-related peptide in the isolated perfused rat kidney. Saussine, C., Massfelder, T., Parnin, F., Judes, C., Simeoni, U., Helwig, J.J. Kidney Int. (1993) [Pubmed]
  33. Effect of aortic baroreceptor deafferentation on plasma vasopressin and oxytocin in the conscious rat. Ciriello, J. Brain Res. (1996) [Pubmed]
  34. Acute hypertension after the local injection of kainic acid into the nucleus tractus solitarii of rats. Talman, W.T., Perrone, M.H., Reis, D.J. Circ. Res. (1981) [Pubmed]
  35. Reduced baroreflex sensitivity with volume loading in conscious dogs. Vatner, S.F., Boettcher, D.H., Heyndrickx, G.R., McRitchie, R.J. Circ. Res. (1975) [Pubmed]
  36. Peptidergic modulation of mechanotransduction in rat arterial baroreceptors. Yang, M.Y., Andresen, M.C. Circ. Res. (1990) [Pubmed]
  37. Cardiopulmonary baroreflexes fail to modulate sympathetic responses during isometric exercise in humans: direct evidence from microneurographic studies. Sanders, J.S., Ferguson, D.W. J. Am. Coll. Cardiol. (1988) [Pubmed]
  38. Baroreceptor influences on oxytocin and vasopressin secretion. Morris, M., Alexander, N. Hypertension (1989) [Pubmed]
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