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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Beta-globin haplotypes from blood spots for follow-up of newborn hemoglobinopathy screening.

The inheritance of sickle-cell anemia upon the background of the major beta-globin gene cluster haplotypes has been associated with differing risks for major organ failure, and more recently with response to hydroxyurea treatment. Early identification of beta-globin haplotypes in individuals with sickle-cell anemia may be a clinically useful prognostic factor for severity of disease expression. This report describes the use of whole-blood spots on filter papers from newborn hemoglobinopathy screening for beta-globin gene cluster haplotyping by the polymerase chain reaction.[1]

References

  1. Beta-globin haplotypes from blood spots for follow-up of newborn hemoglobinopathy screening. Hiti, A.L., Zeng, L., Xiang, Q., Lorey, F.W., Powars, D.R. Am. J. Hematol. (1997) [Pubmed]
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