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Diamond, I. et al.

Cellular and molecular neuroscience of alcoholism.

Recent advances in neuroscience have made it possible to investigate the pathophysiology of alcoholism at a cellular and molecular level. Evidence indicates that ethanol affects hormone- and neurotransmitter-activated signal transduction, leading to short-term changes in regulation of cellular functions and long-term changes in gene expression. Such changes in the brain probably underlie many of the acute and chronic neurological events in alcoholism. In addition, genetic vulnerability also plays a role in alcoholism and, perhaps, in alcoholic medical disorders.[1]

References

Cellular and molecular neuroscience of alcoholism. Diamond, I., Gordon, A.S. Physiol. Rev. (1997) [Pubmed]

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