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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cellular and molecular neuroscience of alcoholism.

Recent advances in neuroscience have made it possible to investigate the pathophysiology of alcoholism at a cellular and molecular level. Evidence indicates that ethanol affects hormone- and neurotransmitter-activated signal transduction, leading to short-term changes in regulation of cellular functions and long-term changes in gene expression. Such changes in the brain probably underlie many of the acute and chronic neurological events in alcoholism. In addition, genetic vulnerability also plays a role in alcoholism and, perhaps, in alcoholic medical disorders.[1]


  1. Cellular and molecular neuroscience of alcoholism. Diamond, I., Gordon, A.S. Physiol. Rev. (1997) [Pubmed]
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