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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Natural killer cell receptors and MHC class I interactions.

Natural killer cells express two distinct families of genes encoding receptors for polymorphic MHC class I molecules. Recent advances indicate that immunoreceptor tyrosine-based inhibitory motifs in the cytoplasmic domains of the killer cell inhibitory receptors and Ly-49 receptors recruit the SH2-containing protein tyrosine phosphatases, SHP-1 and SHP-2, resulting in inhibition of natural-killer- and T-cell-mediated cytotoxicity and cytokine secretion.[1]

References

  1. Natural killer cell receptors and MHC class I interactions. Lanier, L.L. Curr. Opin. Immunol. (1997) [Pubmed]
 
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