Gene Review:
PTPN6 - protein tyrosine phosphatase, non-receptor...
Homo sapiens
Synonyms:
HCP, HCPH, HPTP1C, Hematopoietic cell protein-tyrosine phosphatase, PTP-1C, ...
- Chromosomal localization of an SH2-containing tyrosine phosphatase (PTPN6). Plutzky, J., Neel, B.G., Rosenberg, R.D., Eddy, R.L., Byers, M.G., Jani-Sait, S., Shows, T.B. Genomics (1992)
- STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes. Zhang, Q., Wang, H.Y., Marzec, M., Raghunath, P.N., Nagasawa, T., Wasik, M.A. Proc. Natl. Acad. Sci. U.S.A. (2005)
- SOCS1 and SHP1 hypermethylation in multiple myeloma: implications for epigenetic activation of the Jak/STAT pathway. Chim, C.S., Fung, T.K., Cheung, W.C., Liang, R., Kwong, Y.L. Blood (2004)
- Regulation of acidification and apoptosis by SHP-1 and Bcl-2. Thangaraju, M., Sharma, K., Leber, B., Andrews, D.W., Shen, S.H., Srikant, C.B. J. Biol. Chem. (1999)
- Role of Host Protein Tyrosine Phosphatase SHP-1 in Leishmania donovani-Induced Inhibition of Nitric Oxide Production. Forget, G., Gregory, D.J., Whitcombe, L.A., Olivier, M. Infect. Immun. (2006)
- Impaired motor imagery in right hemiparetic cerebral palsy. Mutsaarts, M., Steenbergen, B., Bekkering, H. Neuropsychologia (2007)
- Regulation of immune responses through inhibitory receptors. Long, E.O. Annu. Rev. Immunol. (1999)
- NK cell receptors. Lanier, L.L. Annu. Rev. Immunol. (1998)
- Signaling through the hematopoietic cytokine receptors. Ihle, J.N., Witthuhn, B.A., Quelle, F.W., Yamamoto, K., Silvennoinen, O. Annu. Rev. Immunol. (1995)
- Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling. Ono, M., Okada, H., Bolland, S., Yanagi, S., Kurosaki, T., Ravetch, J.V. Cell (1997)
- Inhibitory and stimulatory effects of somatostatin on two human pancreatic cancer cell lines: a primary role for tyrosine phosphatase SHP-1. Douziech, N., Calvo, E., Coulombe, Z., Muradia, G., Bastien, J., Aubin, R.A., Lajas, A., Morisset, J. Endocrinology (1999)
- Octapeptide somatostatin analog SMS 201-995 induces translocation of intracellular PTP1C to membranes in MCF-7 human breast adenocarcinoma cells. Srikant, C.B., Shen, S.H. Endocrinology (1996)
- Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein. Li, R.Y., Gaits, F., Ragab, A., Ragab-Thomas, J.M., Chap, H. EMBO J. (1995)
- Negative regulation of the SHPTP1 protein tyrosine phosphatase by protein kinase C delta in response to DNA damage. Yoshida, K., Kufe, D. Mol. Pharmacol. (2001)
- Lack of phosphotyrosine phosphatase SHP-1 expression in malignant T-cell lymphoma cells results from methylation of the SHP-1 promoter. Zhang, Q., Raghunath, P.N., Vonderheid, E., Odum, N., Wasik, M.A. Am. J. Pathol. (2000)
- The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells. Huber, M., Izzi, L., Grondin, P., Houde, C., Kunath, T., Veillette, A., Beauchemin, N. J. Biol. Chem. (1999)
- Interaction of growth hormone-activated STATs with SH2-containing phosphotyrosine phosphatase SHP-1 and nuclear JAK2 tyrosine kinase. Ram, P.A., Waxman, D.J. J. Biol. Chem. (1997)
- Human protein tyrosine phosphatase 1C (PTPN6) gene structure: alternate promoter usage and exon skipping generate multiple transcripts. Banville, D., Stocco, R., Shen, S.H. Genomics (1995)
- SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates. Adachi, T., Wienands, J., Wakabayashi, C., Yakura, H., Reth, M., Tsubata, T. J. Biol. Chem. (2001)
- The protein-tyrosine phosphatase SHP-1 associates with the phosphorylated immunoreceptor tyrosine-based activation motif of Fc gamma RIIa to modulate signaling events in myeloid cells. Ganesan, L.P., Fang, H., Marsh, C.B., Tridandapani, S. J. Biol. Chem. (2003)
- High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages. Veillette, A., Thibaudeau, E., Latour, S. J. Biol. Chem. (1998)
- Phosphotyrosine 1173 mediates binding of the protein-tyrosine phosphatase SHP-1 to the epidermal growth factor receptor and attenuation of receptor signaling. Keilhack, H., Tenev, T., Nyakatura, E., Godovac-Zimmermann, J., Nielsen, L., Seedorf, K., Böhmer, F.D. J. Biol. Chem. (1998)
- The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates p120 catenin. Keilhack, H., Hellman, U., van Hengel, J., van Roy, F., Godovac-Zimmermann, J., Böhmer, F.D. J. Biol. Chem. (2000)
- Negative regulation of PYK2/related adhesion focal tyrosine kinase signal transduction by hematopoietic tyrosine phosphatase SHPTP1. Kumar, S., Avraham, S., Bharti, A., Goyal, J., Pandey, P., Kharbanda, S. J. Biol. Chem. (1999)
- Analysis of SHP-1-mediated down-regulation of the TRK-T3 oncoprotein identifies Trk-fused gene (TFG) as a novel SHP-1-interacting protein. Roccato, E., Miranda, C., Raho, G., Pagliardini, S., Pierotti, M.A., Greco, A. J. Biol. Chem. (2005)
- The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes. Fanger, N.A., Cosman, D., Peterson, L., Braddy, S.C., Maliszewski, C.R., Borges, L. Eur. J. Immunol. (1998)
- Actin tyrosine dephosphorylation by the Src homology 1-containing protein tyrosine phosphatase is essential for actin depolymerization after membrane IgM cross-linking. Baba, T., Fusaki, N., Shinya, N., Iwamatsu, A., Hozumi, N. J. Immunol. (2003)
- Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-terminal structure and catalytic activity. Jin, Y.J., Yu, C.L., Burakoff, S.J. J. Biol. Chem. (1999)
- SHP-1 expression in peripheral T cells from patients with Sezary syndrome and in the T cell line HUT-78: implications in JAK3-mediated signaling. León, F., Cespón, C., Franco, A., Lombardía, M., Roldán, E., Escribano, L., Harto, A., González-Porqué, P., Roy, G. Leukemia (2002)
- Positive effects of SH2 domain-containing tyrosine phosphatase SHP-1 on epidermal growth factor- and interferon-gamma-stimulated activation of STAT transcription factors in HeLa cells. You, M., Zhao, Z. J. Biol. Chem. (1997)
- Both SH2 domains are involved in interaction of SHP-1 with the epidermal growth factor receptor but cannot confer receptor-directed activity to SHP-1/SHP-2 chimera. Tenev, T., Keilhack, H., Tomic, S., Stoyanov, B., Stein-Gerlach, M., Lammers, R., Krivtsov, A.V., Ullrich, A., Böhmer, F.D. J. Biol. Chem. (1997)
- FLT3/ITD mutation signaling includes suppression of SHP-1. Chen, P., Levis, M., Brown, P., Kim, K.T., Allebach, J., Small, D. J. Biol. Chem. (2005)
- The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway. Vila-Coro, A.J., Rodríguez-Frade, J.M., Martín De Ana, A., Moreno-Ortíz, M.C., Martínez-A, C., Mellado, M. FASEB J. (1999)
- Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk. Ganju, R.K., Brubaker, S.A., Chernock, R.D., Avraham, S., Groopman, J.E. J. Biol. Chem. (2000)
- Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells. Migone, T.S., Cacalano, N.A., Taylor, N., Yi, T., Waldmann, T.A., Johnston, J.A. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Negative regulation of beta-catenin signaling by tyrosine phosphatase SHP-1 in intestinal epithelial cells. Duchesne, C., Charland, S., Asselin, C., Nahmias, C., Rivard, N. J. Biol. Chem. (2003)