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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer.

Frzb-1 is a secreted protein containing a domain similar to the putative Wnt-binding region of the frizzled family of transmembrane receptors. Frzb-1 is widely expressed in adult mammalian tissues. In the Xenopus gastrula, it is expressed and regulated as a typical Spemann organizer component. Injection of frzb-1 mRNA blocks expression of XMyoD mRNA and leads to embryos with enlarged heads and shortened trunks. Frzb-1 antagonizes the effects of Xwnt-8 ectopic expression in a non-cell-autonomous manner. Cultured cells transfected with a membrane-tethered form of Wnt-1 bind epitope-tagged Frzb-1 in the 10(-10) M range. The results strengthen the view that the Spemann organizer is a source of secreted inhibitory factors.[1]

References

  1. Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. Leyns, L., Bouwmeester, T., Kim, S.H., Piccolo, S., De Robertis, E.M. Cell (1997) [Pubmed]
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