Gene Review:
Wnt1 - wingless-type MMTV integration site family...
Mus musculus
Synonyms:
Int-1, Proto-oncogene Int-1, Proto-oncogene Wnt-1, Wnt-1, sw, ...
Podsypanina,
Li,
Varmus,
Alexander,
Reichsman,
Hinkes,
Lincecum,
Becker,
Cumberledge,
Bernfield,
Daubas,
Tajbakhsh,
Hadchouel,
Primig,
Buckingham,
Li,
Welm,
Podsypanina,
Huang,
Chamorro,
Zhang,
Rowlands,
Egeblad,
Cowin,
Werb,
Tan,
Rosen,
Varmus,
Prieve,
Moon,
Oshima,
Matsunaga,
Fujimura,
Tsukamoto,
Taketo,
Oshima,
Katoh,
- Carcinogenesis in mouse stomach by simultaneous activation of the wnt signaling and prostaglandin e(2) pathway. Oshima, H., Matsunaga, A., Fujimura, T., Tsukamoto, T., Taketo, M.M., Oshima, M. Gastroenterology (2006)
- Dorsal patterning defects in the hindbrain, roof plate and skeleton in the dreher (dr(J)) mouse mutant. Manzanares, M., Trainor, P.A., Ariza-McNaughton, L., Nonchev, S., Krumlauf, R. Mech. Dev. (2000)
- Expression of Wnt genes and frizzled 1 and 2 receptors in normal breast epithelium and infiltrating breast carcinoma. Milovanovic, T., Planutis, K., Nguyen, A., Marsh, J.L., Lin, F., Hope, C., Holcombe, R.F. Int. J. Oncol. (2004)
- Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype. Podsypanina, K., Li, Y., Varmus, H.E. BMC medicine [electronic resource]. (2004)
- Mouse mammary tumor virus infection accelerates mammary carcinogenesis in Wnt-1 transgenic mice by insertional activation of int-2/Fgf-3 and hst/Fgf-4. Shackleford, G.M., MacArthur, C.A., Kwan, H.C., Varmus, H.E. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice. Alexander, C.M., Reichsman, F., Hinkes, M.T., Lincecum, J., Becker, K.A., Cumberledge, S., Bernfield, M. Nat. Genet. (2000)
- Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. Leyns, L., Bouwmeester, T., Kim, S.H., Piccolo, S., De Robertis, E.M. Cell (1997)
- The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum. McMahon, A.P., Joyner, A.L., Bradley, A., McMahon, J.A. Cell (1992)
- Dormant wnt-initiated mammary cancer can participate in reconstituting functional mammary glands. Gestl, S.A., Leonard, T.L., Biddle, J.L., Debies, M.T., Gunther, E.J. Mol. Cell. Biol. (2007)
- Expression and regulation of WNT1 in human cancer: up-regulation of WNT1 by beta-estradiol in MCF-7 cells. Katoh, M. Int. J. Oncol. (2003)
- Wnt-1 inhibits nerve growth factor-induced differentiation of PC12 cells by preventing the induction of some but not all late-response genes. Chou, A.H., Zheng, S., Itsukaichi, T., Howard, B.D. Brain Res. Mol. Brain Res. (2000)
- The mouse Pax2(1Neu) mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney. Favor, J., Sandulache, R., Neuhäuser-Klaus, A., Pretsch, W., Chatterjee, B., Senft, E., Wurst, W., Blanquet, V., Grimes, P., Spörle, R., Schughart, K. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin. González-Sancho, J.M., Brennan, K.R., Castelo-Soccio, L.A., Brown, A.M. Mol. Cell. Biol. (2004)
- Myf5 is a novel early axonal marker in the mouse brain and is subjected to post-transcriptional regulation in neurons. Daubas, P., Tajbakhsh, S., Hadchouel, J., Primig, M., Buckingham, M. Development (2000)
- The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum. Chi, C.L., Martinez, S., Wurst, W., Martin, G.R. Development (2003)
- Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh. Riccomagno, M.M., Takada, S., Epstein, D.J. Genes Dev. (2005)
- Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. Lagutin, O.V., Zhu, C.C., Kobayashi, D., Topczewski, J., Shimamura, K., Puelles, L., Russell, H.R., McKinnon, P.J., Solnica-Krezel, L., Oliver, G. Genes Dev. (2003)
- Neural crest-directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development. Dunn, K.J., Williams, B.O., Li, Y., Pavan, W.J. Proc. Natl. Acad. Sci. U.S.A. (2000)
- FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate. Liu, A., Losos, K., Joyner, A.L. Development (1999)
- Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Danielian, P.S., Muccino, D., Rowitch, D.H., Michael, S.K., McMahon, A.P. Curr. Biol. (1998)
- Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Castelo-Branco, G., Wagner, J., Rodriguez, F.J., Kele, J., Sousa, K., Rawal, N., Pasolli, H.A., Fuchs, E., Kitajewski, J., Arenas, E. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis. Gunther, E.J., Moody, S.E., Belka, G.K., Hahn, K.T., Innocent, N., Dugan, K.D., Cardiff, R.D., Chodosh, L.A. Genes Dev. (2003)
- A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Prakash, N., Brodski, C., Naserke, T., Puelles, E., Gogoi, R., Hall, A., Panhuysen, M., Echevarria, D., Sussel, L., Weisenhorn, D.M., Martinez, S., Arenas, E., Simeone, A., Wurst, W. Development (2006)
- Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Li, Y., Welm, B., Podsypanina, K., Huang, S., Chamorro, M., Zhang, X., Rowlands, T., Egeblad, M., Cowin, P., Werb, Z., Tan, L.K., Rosen, J.M., Varmus, H.E. Proc. Natl. Acad. Sci. U.S.A. (2003)
- LeX is expressed by principle progenitor cells in the embryonic nervous system, is secreted into their environment and binds Wnt-1. Capela, A., Temple, S. Dev. Biol. (2006)
- Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Korinek, V., Barker, N., Willert, K., Molenaar, M., Roose, J., Wagenaar, G., Markman, M., Lamers, W., Destree, O., Clevers, H. Mol. Cell. Biol. (1998)
- Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain. Lee, S.M., Danielian, P.S., Fritzsch, B., McMahon, A.P. Development (1997)
- Msx1 is required for dorsal diencephalon patterning. Bach, A., Lallemand, Y., Nicola, M.A., Ramos, C., Mathis, L., Maufras, M., Robert, B. Development (2003)
- Multiple mechanisms for Wnt11-mediated repression of the canonical Wnt signaling pathway. Maye, P., Zheng, J., Li, L., Wu, D. J. Biol. Chem. (2004)
- Murine Frizzled-1 behaves as an antagonist of the canonical Wnt/beta-catenin signaling. Roman-Roman, S., Shi, D.L., Stiot, V., Haÿ, E., Vayssière, B., Garcia, T., Baron, R., Rawadi, G. J. Biol. Chem. (2004)
- Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models. Du, Z., Podsypanina, K., Huang, S., McGrath, A., Toneff, M.J., Bogoslovskaia, E., Zhang, X., Moraes, R.C., Fluck, M., Allred, D.C., Lewis, M.T., Varmus, H.E., Li, Y. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice. Guo, C., Qiu, H.Y., Huang, Y., Chen, H., Yang, R.Q., Chen, S.D., Johnson, R.L., Chen, Z.F., Ding, Y.Q. Development (2007)
- Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia. Ligon, K.L., Echelard, Y., Assimacopoulos, S., Danielian, P.S., Kaing, S., Grove, E.A., McMahon, A.P., Rowitch, D.H. Development (2003)
- Differential activation of Myf5 and MyoD by different Wnts in explants of mouse paraxial mesoderm and the later activation of myogenesis in the absence of Myf5. Tajbakhsh, S., Borello, U., Vivarelli, E., Kelly, R., Papkoff, J., Duprez, D., Buckingham, M., Cossu, G. Development (1998)
- Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription. Staal, F.J., Meeldijk, J., Moerer, P., Jay, P., van de Weerdt, B.C., Vainio, S., Nolan, G.P., Clevers, H. Eur. J. Immunol. (2001)
- Stromelysin-1 and mesothelin are differentially regulated by Wnt-5a and Wnt-1 in C57mg mouse mammary epithelial cells. Prieve, M.G., Moon, R.T. BMC Dev. Biol. (2003)
- Swaying is a mutant allele of the proto-oncogene Wnt-1. Thomas, K.R., Musci, T.S., Neumann, P.E., Capecchi, M.R. Cell (1991)
- A mouse mammary tumor virus-Wnt-1 transgene induces mammary gland hyperplasia and tumorigenesis in mice lacking estrogen receptor-alpha. Bocchinfuso, W.P., Hively, W.P., Couse, J.F., Varmus, H.E., Korach, K.S. Cancer Res. (1999)