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Kokura, S. et al.

Efficacy of hyperthermia and polyunsaturated fatty acids on experimental carcinoma.

We investigated the efficacy of hyperthermia and gamma-linolenic acid on experimental carcinoma. This study focused on polyunsaturated fatty acids that are substrates for free radical reactions. Oleic acid, linolenic acid, alpha-linolenic acid, or gamma-linolenic acid was injected into the arteries feeding AH109A carcinoma implanted into rat hind limbs. Among these, gamma-linolenic acid had the greatest effect on tumor tissue lipid peroxidation and demonstrated an antitumor effect. Consequently, gamma-linolenic acid injection into the feeding artery of a tumor was performed immediately prior to hyperthermia. This combination therapy induced a high level of lipid peroxidation in tumor tissue and a significant antitumor effect. Hyperthermia combined with gamma-linolenic acid produces free radical reactions by increasing the radical reaction substrate and may be an effective anticancer modality.[1]

References

Efficacy of hyperthermia and polyunsaturated fatty acids on experimental carcinoma. Kokura, S., Yoshikawa, T., Kaneko, T., Iinuma, S., Nishimura, S., Matsuyama, K., Naito, Y., Yoshida, N., Kondo, M. Cancer Res. (1997) [Pubmed]

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