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Chemical Compound Review

Industrene 120     (9E,12E,15E)-octadeca- 9,12,15-trienoic acid

Synonyms: Perilla oil, CCRIS 656, Shiso oil, Oils, perilla, CCRIS 7126, ...
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Disease relevance of alpha-Linolenic acid


Psychiatry related information on alpha-Linolenic acid

  • The effects of dietary alpha-linolenic acid deficiency were studied in a model of learning, the Morris water maze, and on the following effects of morphine: increase in locomotor activity, modifications of rectal temperature and analgesia [6].
  • After optimization, the standard in vitro conditions for the measurement of delta6-desaturase activity were as follows: 60 micromol x L(-1) alpha-linolenic acid (C18:3n-3), reaction time of 20 min and protein content of 0.4 mg [7].
  • Dietary deprivation of linolenic acid (LNA) during the perinatal life on the other hand, resulted in losses of DHA from cerebral PLs [M. Schiefermeier, E. Yavin, n-3 deficient and DHA-enriched diets during critical periods of the developing prenatal rat brain, J. Lipid Res. 43 (2002) 124-131] [8].

High impact information on alpha-Linolenic acid


Chemical compound and disease context of alpha-Linolenic acid


Biological context of alpha-Linolenic acid


Anatomical context of alpha-Linolenic acid


Associations of alpha-Linolenic acid with other chemical compounds


Gene context of alpha-Linolenic acid

  • An S. cerevisiae gpx1 Delta/gpx2 Delta/gpx3 Delta mutant was defective for growth in medium supplemented with the oxidation-sensitive polyunsaturated fatty acid linolenate (18:3) [34].
  • Genetic analyses using plasmids carrying the genes, PHO5 and PHO3, that code for repressible APase and constitutive APase, respectively, showed that linolenic acid induced the formation of repressible APase [35].
  • It is concluded that, with the exception of IL-6 production, a modest increase in intake of either ALNA or EPA+DHA does not influence the functional activity of mononuclear cells [36].
  • Moreover, conjugated linolenic acid from bitter gourd at lower concentrations that was without effects by itself synergistically stimulated TNF-alpha-induced apoptosis [37].
  • ERK kinase inhibitors significantly reduced the anti-apoptotic effects of linolenic acid [38].

Analytical, diagnostic and therapeutic context of alpha-Linolenic acid


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  19. Oligogalacturonides and chitosan activate plant defensive genes through the octadecanoid pathway. Doares, S.H., Syrovets, T., Weiler, E.W., Ryan, C.A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
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  21. Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives. Rubbo, H., Radi, R., Trujillo, M., Telleri, R., Kalyanaraman, B., Barnes, S., Kirk, M., Freeman, B.A. J. Biol. Chem. (1994) [Pubmed]
  22. Identification of a jasmonate-regulated allene oxide synthase that metabolizes 9-hydroperoxides of linoleic and linolenic acids. Itoh, A., Schilmiller, A.L., McCaig, B.C., Howe, G.A. J. Biol. Chem. (2002) [Pubmed]
  23. Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B. Sinha, S., Perdomo, G., Brown, N.F., O'Doherty, R.M. J. Biol. Chem. (2004) [Pubmed]
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  26. Effect of dietary alpha-linolenate on platelet-activating factor production in rat peritoneal polymorphonuclear leukocytes. Horii, T., Satouchi, K., Kobayashi, Y., Saito, K., Watanabe, S., Yoshida, Y., Okuyama, H. J. Immunol. (1991) [Pubmed]
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  29. The DEFECTIVE IN ANTHER DEHISCIENCE gene encodes a novel phospholipase A1 catalyzing the initial step of jasmonic acid biosynthesis, which synchronizes pollen maturation, anther dehiscence, and flower opening in Arabidopsis. Ishiguro, S., Kawai-Oda, A., Ueda, J., Nishida, I., Okada, K. Plant Cell (2001) [Pubmed]
  30. Precursor role of arachidonic acid in release of slow reacting substance from rat basophilic leukemia cells. Jakschik, B.A., Falkenhein, S., Parker, C.W. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
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  32. Demethoxy-Q, an intermediate of coenzyme Q biosynthesis, fails to support respiration in Saccharomyces cerevisiae and lacks antioxidant activity. Padilla, S., Jonassen, T., Jiménez-Hidalgo, M.A., Fernández-Ayala, D.J., López-Lluch, G., Marbois, B., Navas, P., Clarke, C.F., Santos-Ocaña, C. J. Biol. Chem. (2004) [Pubmed]
  33. A novel class of oxylipins, sn1-O-(12-oxophytodienoyl)-sn2-O-(hexadecatrienoyl)-monogalactosyl Diglyceride, from Arabidopsis thaliana. Stelmach, B.A., Müller, A., Hennig, P., Gebhardt, S., Schubert-Zsilavecz, M., Weiler, E.W. J. Biol. Chem. (2001) [Pubmed]
  34. Saccharomyces cerevisiae expresses three phospholipid hydroperoxide glutathione peroxidases. Avery, A.M., Avery, S.V. J. Biol. Chem. (2001) [Pubmed]
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  36. Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects. Wallace, F.A., Miles, E.A., Calder, P.C. Br. J. Nutr. (2003) [Pubmed]
  37. Control of life cycle of mouse adipogenic 3T3-L1 cells by dietary lipids and metabolic factors. Nishimura, K., Hatano, Y., Setoyama, T., Tsumagari, H., Miyashita, K., Lu, S., Jisaka, M., Nagaya, T., Yokota, K. Appl. Biochem. Biotechnol. (2004) [Pubmed]
  38. Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1. Katsuma, S., Hatae, N., Yano, T., Ruike, Y., Kimura, M., Hirasawa, A., Tsujimoto, G. J. Biol. Chem. (2005) [Pubmed]
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