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Chemical Compound Review

AG-F-70324     octadeca-6,9,12-trienoic acid

Synonyms: AG-J-98184, KBioGR_000058, KBioSS_000058, ACMC-209kod, ANW-31067, ...
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Disease relevance of gamma-Linolenic acid


Psychiatry related information on gamma-Linolenic acid

  • During the critical period of postnatal development in mammals, AA is supplied preformed, directly from the milk or derived from precursor fatty acids such as gamma-linolenic acid (GLA; 18:3n-6) [6].
  • The objective of this study was to test the effect of a supplement of blackcurrant seed oil (BSO), a rich source of gamma-linolenic acid (C18:3n-6) on the resting blood pressure (BP) and cardiovascular reactivity to a psychological stress in borderline hypertensive individuals [7].

High impact information on gamma-Linolenic acid


Chemical compound and disease context of gamma-Linolenic acid


Biological context of gamma-Linolenic acid


Anatomical context of gamma-Linolenic acid


Associations of gamma-Linolenic acid with other chemical compounds


Gene context of gamma-Linolenic acid


Analytical, diagnostic and therapeutic context of gamma-Linolenic acid


  1. Gamma-linolenic acid in diabetic neuropathy. Jamal, G.A., Carmichael, H., Weir, A.I. Lancet (1986) [Pubmed]
  2. Selective cytotoxicity of lithium gamma-linolenic acid in human T cells chronically and productively infected with HIV. Mpanju, O., Winther, M., Manning, J., Craib, K., Montaner, J., O'Shaugnessy, M., Conway, B. Antivir. Ther. (Lond.) (1997) [Pubmed]
  3. Efficacy of hyperthermia and polyunsaturated fatty acids on experimental carcinoma. Kokura, S., Yoshikawa, T., Kaneko, T., Iinuma, S., Nishimura, S., Matsuyama, K., Naito, Y., Yoshida, N., Kondo, M. Cancer Res. (1997) [Pubmed]
  4. Comparison of the effects of ascorbyl gamma-linolenic acid and gamma-linolenic acid in the correction of neurovascular deficits in diabetic rats. Cameron, N.E., Cotter, M.A. Diabetologia (1996) [Pubmed]
  5. Components of the insulin resistance syndrome in seven-year-old children: relations with birth weight and the polyunsaturated fatty acid content of umbilical cord plasma phospholipids. Rump, P., Popp-Snijders, C., Heine, R.J., Hornstra, G. Diabetologia (2002) [Pubmed]
  6. Uptake of 13C-tracer arachidonate and gamma-linolenate by the brain and liver of the suckling rat observed using 13C-NMR. Likhodii, S.S., Cunnane, S.C. J. Neurochem. (1999) [Pubmed]
  7. Resting blood pressure and cardiovascular reactivity to mental arithmetic in mild hypertensive males supplemented with blackcurrant seed oil. Deferne, J.L., Leeds, A.R. Journal of human hypertension. (1996) [Pubmed]
  8. Identification and characterization of an enzyme involved in the elongation of n-6 and n-3 polyunsaturated fatty acids. Parker-Barnes, J.M., Das, T., Bobik, E., Leonard, A.E., Thurmond, J.M., Chaung, L.T., Huang, Y.S., Mukerji, P. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  9. Induction of apoptosis by arachidonic acid in chronic myeloid leukemia cells. Rizzo, M.T., Regazzi, E., Garau, D., Akard, L., Dugan, M., Boswell, H.S., Rizzoli, V., Carlo-Stella, C. Cancer Res. (1999) [Pubmed]
  10. Regulation of the expression of E-cadherin on human cancer cells by gamma-linolenic acid (GLA). Jiang, W.G., Hiscox, S., Hallett, M.B., Horrobin, D.F., Mansel, R.E., Puntis, M.C. Cancer Res. (1995) [Pubmed]
  11. Evidence against Calcium as a Mediator of Mitochondrial Dysfunction during Apoptosis Induced by Arachidonic Acid and Other Free Fatty Acids. Maia, R.C., Culver, C.A., Laster, S.M. J. Immunol. (2006) [Pubmed]
  12. Diabetic neuropathy: pathogenesis and therapy. Vinik, A.I. Am. J. Med. (1999) [Pubmed]
  13. n-6 polyunsaturated fatty acids enhance the activities of ceftazidime and amikacin in experimental sepsis caused by multidrug-resistant Pseudomonas aeruginosa. Giamarellos-Bourboulis, E.J., Mouktaroudi, M., Adamis, T., Koussoulas, V., Baziaka, F., Perrea, D., Karayannacos, P.E., Giamarellou, H. Antimicrob. Agents Chemother. (2004) [Pubmed]
  14. Effect of epinephrine on the oxidative desaturation of fatty acids in the rat. de Gómez Dumm, N.T., de Alaniz, M.J., Brenner, R.R. J. Lipid Res. (1976) [Pubmed]
  15. Dietary gamma-linolenic acid lowers blood pressure and alters aortic reactivity and cholesterol metabolism in hypertension. Engler, M.M., Engler, M.B., Erickson, S.K., Paul, S.M. J. Hypertens. (1992) [Pubmed]
  16. Effect of dietary GLA+/-tamoxifen on the growth, ER expression and fatty acid profile of ER positive human breast cancer xenografts. Kenny, F.S., Gee, J.M., Nicholson, R.I., Ellis, I.O., Morris, T.M., Watson, S.A., Bryce, R.P., Robertson, J.F. Int. J. Cancer (2001) [Pubmed]
  17. Essential fatty acids in the management of impaired nerve function in diabetes. Horrobin, D.F. Diabetes (1997) [Pubmed]
  18. Manganese lipoxygenase. Purification and characterization. Su, C., Oliw, E.H. J. Biol. Chem. (1998) [Pubmed]
  19. Selective modulation of the human platelet thromboxane A2/prostaglandin H2 receptor by eicosapentaenoic and docosahexaenoic acids in intact platelets and solubilized platelet membranes. Parent, C.A., Lagarde, M., Venton, D.L., Le Breton, G.C. J. Biol. Chem. (1992) [Pubmed]
  20. Effects of alpha-lipoic acid on neurovascular function in diabetic rats: interaction with essential fatty acids. Cameron, N.E., Cotter, M.A., Horrobin, D.H., Tritschler, H.J. Diabetologia (1998) [Pubmed]
  21. Alteration of the cellular fatty acid profile and the production of eicosanoids in human monocytes by gamma-linolenic acid. Pullman-Mooar, S., Laposata, M., Lem, D., Holman, R.T., Leventhal, L.J., DeMarco, D., Zurier, R.B. Arthritis Rheum. (1990) [Pubmed]
  22. Prevention of nerve conduction deficit in diabetic rats by polyunsaturated fatty acids. Head, R.J., McLennan, P.L., Raederstorff, D., Muggli, R., Burnard, S.L., McMurchie, E.J. Am. J. Clin. Nutr. (2000) [Pubmed]
  23. Dietary gamma-linolenic acid modulates macrophage-vascular smooth muscle cell interactions. Evidence for a macrophage-derived soluble factor that downregulates DNA synthesis in smooth muscle cells. Fan, Y.Y., Ramos, K.S., Chapkin, R.S. Arterioscler. Thromb. Vasc. Biol. (1995) [Pubmed]
  24. Rapid modulation of lung and liver macrophage phospholipid fatty acids in endotoxemic rats by continuous enteral feeding with n-3 and gamma-linolenic fatty acids. Palombo, J.D., DeMichele, S.J., Lydon, E.E., Gregory, T.J., Banks, P.L., Forse, R.A., Bistrian, B.R. Am. J. Clin. Nutr. (1996) [Pubmed]
  25. Suppression of monosodium urate crystal-induced acute inflammation by diets enriched with gamma-linolenic acid and eicosapentaenoic acid. Tate, G.A., Mandell, B.F., Karmali, R.A., Laposata, M., Baker, D.G., Schumacher, H.R., Zurier, R.B. Arthritis Rheum. (1988) [Pubmed]
  26. Acyl carriers used as substrates by the desaturases and elongases involved in very long-chain polyunsaturated fatty acids biosynthesis reconstituted in yeast. Domergue, F., Abbadi, A., Ott, C., Zank, T.K., Zähringer, U., Heinz, E. J. Biol. Chem. (2003) [Pubmed]
  27. The effectiveness of treatments of diabetic autonomic neuropathy is not the same in autonomic nerves supplying different organs. Shotton, H.R., Clarke, S., Lincoln, J. Diabetes (2003) [Pubmed]
  28. Isolation of a delta 6-desaturase gene from the cyanobacterium Synechocystis sp. strain PCC 6803 by gain-of-function expression in Anabaena sp. strain PCC 7120. Reddy, A.S., Nuccio, M.L., Gross, L.M., Thomas, T.L. Plant Mol. Biol. (1993) [Pubmed]
  29. Peroxisome proliferator activated receptor-gamma (PPAR-gamma) mediates the action of gamma linolenic acid in breast cancer cells. Jiang, W.G., Redfern, A., Bryce, R.P., Mansel, R.E. Prostaglandins Leukot. Essent. Fatty Acids (2000) [Pubmed]
  30. Gamma-Linolenic acid regulates the expression and secretion of SPARC in human cancer cells. Watkins, G., Martin, T.A., Bryce, R., Mansel, R.E., Jiang, W.G. Prostaglandins Leukot. Essent. Fatty Acids (2005) [Pubmed]
  31. Dietary gamma-linolenic acid suppresses aortic smooth muscle cell proliferation and modifies atherosclerotic lesions in apolipoprotein E knockout mice. Fan, Y.Y., Ramos, K.S., Chapkin, R.S. J. Nutr. (2001) [Pubmed]
  32. Purification and characterization of recombinant human cyclooxygenase-2. Percival, M.D., Ouellet, M., Vincent, C.J., Yergey, J.A., Kennedy, B.P., O'Neill, G.P. Arch. Biochem. Biophys. (1994) [Pubmed]
  33. Anticancer effects of free polyunsaturated fatty acids in an oily lymphographic agent following intrahepatic arterial administration to a rabbit bearing VX-2 tumor. Hayashi, Y., Fukushima, S., Kishimoto, S., Kawaguchi, T., Numata, M., Isoda, Y., Hirano, J., Nakano, M. Cancer Res. (1992) [Pubmed]
  34. Intravesical chemotherapy with gamma linolenic acid becomes a reality. Schellhammer, P.F. J. Urol. (1998) [Pubmed]
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