Localization of mRNA for fatty acid transport protein in developing and mature brain of rats.
Gene expression for rat fatty acid transport protein ( FATP) and fatty acid translocase (FAT) were examined by Northern and in situ hybridization analysis. In Northern blot analysis of developing brain, FATP mRNA was detected weakly throughout all developing stages without any changes in the expression level, while no gene expression for FAT mRNA was detected at any stages. By in situ hybridization histochemistry, intense expression was seen in the ventricular germinal zone on pre- and perinatal stages, whereas distinct expression was observed in the cerebellar Purkinje and granule cell during postpostnatal development. No expression was detected in the cerebellar external granule cell layer. Because of the high expression of FATP mRNA in the embryonic ventricular zone and the postnatal cerebellar cortical neurons in parallel to the gene expression for fatty acid binding protein (FABP) which we have recently reported, co-operated involvement of FATP and FABP in the active uptake of long-chain fatty acids is plausible in these cells.[1]References
- Localization of mRNA for fatty acid transport protein in developing and mature brain of rats. Utsunomiya, A., Owada, Y., Yoshimoto, T., Kondo, H. Brain Res. Mol. Brain Res. (1997) [Pubmed]
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