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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase.

The c-Jun NH2-terminal kinase ( JNK) group of mitogen-activated protein (MAP) kinases is activated by phosphorylation on Thr and Tyr. Here we report the molecular cloning of a new member of the mammalian MAP kinase kinase group ( MKK7) that functions as an activator of JNK. In vitro protein kinase assays demonstrate that MKK7 phosphorylates and activates JNK, but not the p38 or extracellular signal-regulated kinase groups of MAP kinase. Expression of MKK7 in cultured cells causes activation of the JNK signal transduction pathway. MKK7 is therefore established to be a novel component of the JNK signal transduction pathway.[1]

References

  1. Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. Tournier, C., Whitmarsh, A.J., Cavanagh, J., Barrett, T., Davis, R.J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
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