- Characterization of a Chinese hamster ovary cell line with acquired resistance to the bisdioxopiperazine dexrazoxane (ICRF-187) catalytic inhibitor of topoisomerase II. Hasinoff, B.B., Kuschak, T.I., Creighton, A.M., Fattman, C.L., Allan, W.P., Thampatty, P., Yalowich, J.C. Biochem. Pharmacol. (1997)