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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Cloning, human chromosomal assignment, and adipose and hepatic expression of the CL-6/INSIG1 gene.

Rat CL-6 is the most highly insulin-induced gene in a liver cell line and is expressed in proliferating liver during regeneration and development. CL-6 is now denoted INSIG1 (insulin-induced gene 1). Human INSIG1 was isolated and found to be 80% identical to the rat gene within the translated region. It was located on human chromosome 7 within band q36. The human INSIG1 promoter conferred a high level of expression in both liver and fibroblast cell lines. INSIG1 expression was upregulated at the transcriptional level in rat regenerating liver and induced in a model of murine adipocyte differentiation, suggesting that INSIG1 may play a role in growth and differentiation of tissues involved in metabolic control.[1]

References

  1. Cloning, human chromosomal assignment, and adipose and hepatic expression of the CL-6/INSIG1 gene. Peng, Y., Schwarz, E.J., Lazar, M.A., Genin, A., Spinner, N.B., Taub, R. Genomics (1997) [Pubmed]
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