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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Skeletal functions of vitamin K-dependent proteins: not just for clotting anymore.

Osteocalcin and matrix Gla protein (MGP) are two vitamin K-dependent proteins present in bone and cartilage. Transgenic mice models were recently developed to isolate the function of each of these proteins. While osteocalcin-deficient mice have increased bone formation, MGP-deficient mice have abnormal calcification leading to osteopenia, fractures, and premature death owing to arterial calcification.[1]


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