Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Knirr, S. et al.

Somatic mesoderm differentiation and the development of a subset of pericardial cells depend on the not enough muscles (nem) locus, which contains the inscuteable gene and the intron located gene, skittles.

Not enough muscles (nem) mutants of Drosophila reveal defects in the development of embryonic muscles, a subset of pericardial cells, the CNS and derivatives of the PNS (Burchard, S., Paululat, A., Hinz, U. and Renkawitz-Pohl, R. (1995) The mutant not enough muscles (nem) reveals reduction of the Drosophila embryonic muscle pattern. J. Cell. Sci. 108, 1443-1454). The molecular analysis of the nem locus shows a complex genomic structure. One transcription unit was identified as inscuteable (insc). Within the first intron of insc we find another independent gene, skittles (sktl), which is not affected in nem mutants. insc transcripts are localised apically in neuroblasts and may prefigure the localisation of the protein. The skittles mRNA is ubiquitously distributed during early embryogenesis due to maternal contribution. Later, some enrichment of sktl is observed in the nervous system and the mesoderm. The muscle phenotype shows deletions as well as duplication of specific muscles which is reflected in a change of even-skipped (eve) and KrÃ¼ppel (Kr) expressing cells. Our data suggest a role for insc in the specification process of a subset of muscle progenitors/founders. Furthermore, in insc mutants the eve expressing pericardial cells of the developing heart are significantly reduced in numbers.[1]

References

Somatic mesoderm differentiation and the development of a subset of pericardial cells depend on the not enough muscles (nem) locus, which contains the inscuteable gene and the intron located gene, skittles. Knirr, S., Breuer, S., Paululat, A., Renkawitz-Pohl, R. Mech. Dev. (1997) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.