High impact information on sktl

• In this article, we provide biochemical evidence that ASH2 binds directly to Skittles (SKTL), a predicted phosphatidylinositol 4-phosphate 5-kinase, and genetic evidence that the association of these proteins is functionally significant [1].
• The direct interaction between ASH2, a Drosophila trithorax group protein, and SKTL, a nuclear phosphatidylinositol 4-phosphate 5-kinase, implies a role for phosphatidylinositol 4,5-bisphosphate in maintaining transcriptionally active chromatin [1].
• Our analysis indicates that skittles is required for cell viability, germline development, and the proper structural development of sensory bristles [2].
• We have cloned and generated mutations in a Drosophila PIP5K type I (skittles) [2].
• Later, some enrichment of sktl is observed in the nervous system and the mesoderm [3].

Biological context of sktl

• The skittles mRNA is ubiquitously distributed during early embryogenesis due to maternal contribution [3].

Associations of sktl with chemical compounds

• skittles, a Drosophila phosphatidylinositol 4-phosphate 5-kinase, is required for cell viability, germline development and bristle morphology, but not for neurotransmitter release [2].

Other interactions of sktl

• Somatic mesoderm differentiation and the development of a subset of pericardial cells depend on the not enough muscles (nem) locus, which contains the inscuteable gene and the intron located gene, skittles [3].

References