The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Pharmacokinetics and clearance of ganciclovir during continuous hemodiafiltration.

OBJECTIVE: To evaluate the ganciclovir pharmacokinetics and clearance during continuous venovenous hemodiafiltration. DESIGN: Case report. SETTING: General intensive care unit of a tertiary care emergency department. PATIENTS: A 63-yr-old female who has a history of active behçet's disease that has been controlled with oral prednisolone, and who has chronic renal failure. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: A 5-mg/kg dosage of ganciclovir was administered intravenously over a 60-min period under continuous venovenous hemodiafiltration. Samples from the arterial and venous blood catheters and from the ultradiafiltrate were collected over the next 12 hrs to calculate pharmacokinetic parameters and clearance of hemodiafiltration. The pharmacokinetic parameters were as follows: half-life of elimination phase 12.6 hrs; total clearance 0.55 mL/min/kg; and volume distribution of steady state 27.07 L. The clearance of hemodiafiltration was 0.63 mL/min/kg. CONCLUSION: Continuous venovenous hemodiafiltration is effective in removing ganciclovir from the blood.[1]

References

  1. Pharmacokinetics and clearance of ganciclovir during continuous hemodiafiltration. Gando, S., Kameue, T., Nanzaki, S., Hayakawa, T., Nakanishi, Y. Crit. Care Med. (1998) [Pubmed]
 
WikiGenes - Universities