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Chemical Compound Review

Cytovene     2-amino-9-(1,3- dihydroxypropan-2...

Synonyms: Cymevene, Citovirax, Cymevan, Cymeven, Gancyclovir, ...
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Disease relevance of Gancyclovir


Psychiatry related information on Gancyclovir


High impact information on Gancyclovir


Chemical compound and disease context of Gancyclovir


Biological context of Gancyclovir


Anatomical context of Gancyclovir


Associations of Gancyclovir with other chemical compounds


Gene context of Gancyclovir

  • We then showed that additional ribozymes directed against PSMA7 RNA inhibited HCV IRES activity in two assay systems: GCV resistance in the HeLa IRES TK reporter cell system and a transient transfection assay performed with a bicistronic Renilla-HCV IRES-firefly luciferase reporter in Huh7 cells [28].
  • Combinational injection of a single dose of Ad5-hTERT-E1 and Ad5-RSV-hsvTK vector resulted in significant tumor suppression and regression after ganciclovir treatment [29].
  • In addition, ganciclovir reduced the number of enteroendocrine cells producing gastric inhibitory polypeptide, substance-P, somatostatin and serotonin [30].
  • Inhibition of HCMV DNA synthesis by ganciclovir did not influence TSP-1 reduction whereas the antisense oligonucleotide ISIS 2922, complementary to HCMV immediate-early mRNA, completely prevented the HCMV-mediated TSP-1 suppression [31].
  • In summary, we demonstrated the selective targeting of colorectal cancers with activated beta-catenin by AdTOP-CMV-TK and GCV treatment in animal models, as well as its therapeutic potential for colon cancer metastasized to liver [32].

Analytical, diagnostic and therapeutic context of Gancyclovir


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  9. Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice. Bush, T.G., Savidge, T.C., Freeman, T.C., Cox, H.J., Campbell, E.A., Mucke, L., Johnson, M.H., Sofroniew, M.V. Cell (1998) [Pubmed]
  10. Oral ganciclovir for the prevention of cytomegalovirus disease in persons with AIDS. Roche Cooperative Oral Ganciclovir Study Group. Spector, S.A., McKinley, G.F., Lalezari, J.P., Samo, T., Andruczk, R., Follansbee, S., Sparti, P.D., Havlir, D.V., Simpson, G., Buhles, W., Wong, R., Stempien, M. N. Engl. J. Med. (1996) [Pubmed]
  11. Oral ganciclovir as maintenance treatment for cytomegalovirus retinitis in patients with AIDS. Syntex Cooperative Oral Ganciclovir Study Group. Drew, W.L., Ives, D., Lalezari, J.P., Crumpacker, C., Follansbee, S.E., Spector, S.A., Benson, C.A., Friedberg, D.N., Hubbard, L., Stempien, M.J. N. Engl. J. Med. (1995) [Pubmed]
  12. Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir. Littler, E., Stuart, A.D., Chee, M.S. Nature (1992) [Pubmed]
  13. Acyclovir and ganciclovir in cytomegalovirus. Moss, G.B. Ann. Intern. Med. (1994) [Pubmed]
  14. Toxicity of combined ganciclovir and zidovudine for cytomegalovirus disease associated with AIDS. An AIDS Clinical Trials Group Study. Hochster, H., Dieterich, D., Bozzette, S., Reichman, R.C., Connor, J.D., Liebes, L., Sonke, R.L., Spector, S.A., Valentine, F., Pettinelli, C. Ann. Intern. Med. (1990) [Pubmed]
  15. Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Chen, S.H., Shine, H.D., Goodman, J.C., Grossman, R.G., Woo, S.L. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  16. Progressive disease due to ganciclovir-resistant cytomegalovirus in immunocompromised patients. Erice, A., Chou, S., Biron, K.K., Stanat, S.C., Balfour, H.H., Jordan, M.C. N. Engl. J. Med. (1989) [Pubmed]
  17. A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells. Sullivan, V., Talarico, C.L., Stanat, S.C., Davis, M., Coen, D.M., Biron, K.K. Nature (1992) [Pubmed]
  18. Epstein-Barr virus-driven gene therapy for EBV-related lymphomas. Franken, M., Estabrooks, A., Cavacini, L., Sherburne, B., Wang, F., Scadden, D.T. Nat. Med. (1996) [Pubmed]
  19. Suppression of erythro-megakaryocytopoiesis and the induction of reversible thrombocytopenia in mice transgenic for the thymidine kinase gene targeted by the platelet glycoprotein alpha IIb promoter. Tronik-Le Roux, D., Roullot, V., Schweitzer, A., Berthier, R., Marguerie, G. J. Exp. Med. (1995) [Pubmed]
  20. A randomized, controlled trial of prophylactic ganciclovir for cytomegalovirus pulmonary infection in recipients of allogeneic bone marrow transplants; The City of Hope-Stanford-Syntex CMV Study Group. Schmidt, G.M., Horak, D.A., Niland, J.C., Duncan, S.R., Forman, S.J., Zaia, J.A. N. Engl. J. Med. (1991) [Pubmed]
  21. Central nervous system side effects of ganciclovir. Davis, C.L., Springmeyer, S., Gmerek, B.J. N. Engl. J. Med. (1990) [Pubmed]
  22. Restoration of cytomegalovirus-specific CD4+ T-lymphocyte responses after ganciclovir and highly active antiretroviral therapy in individuals infected with HIV-1. Komanduri, K.V., Viswanathan, M.N., Wieder, E.D., Schmidt, D.K., Bredt, B.M., Jacobson, M.A., McCune, J.M. Nat. Med. (1998) [Pubmed]
  23. A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells. Sullivan, V., Talarico, C.L., Stanat, S.C., Davis, M., Coen, D.M., Biron, K.K. Nature (1992) [Pubmed]
  24. Re: Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies. Liao, W.C., Chang, W.S., Wu, F.Y. J. Natl. Cancer Inst. (1999) [Pubmed]
  25. Inhibition of immune functions by antiviral drugs. Heagy, W., Crumpacker, C., Lopez, P.A., Finberg, R.W. J. Clin. Invest. (1991) [Pubmed]
  26. Transactivation of the metallothionein promoter in cisplatin-resistant cancer cells: a specific gene therapy strategy. Vandier, D., Calvez, V., Massade, L., Gouyette, A., Mickley, L., Fojo, T., Rixe, O. J. Natl. Cancer Inst. (2000) [Pubmed]
  27. Optimal management of the post-intestinal transplant patient. Horslen, S.P. Gastroenterology (2006) [Pubmed]
  28. Involvement of proteasome alpha-subunit PSMA7 in hepatitis C virus internal ribosome entry site-mediated translation. Krüger, M., Beger, C., Welch, P.J., Barber, J.R., Manns, M.P., Wong-Staal, F. Mol. Cell. Biol. (2001) [Pubmed]
  29. Replication of an adenoviral vector controlled by the human telomerase reverse transcriptase promoter causes tumor-selective tumor lysis. Lanson, N.A., Friedlander, P.L., Schwarzenberger, P., Kolls, J.K., Wang, G. Cancer Res. (2003) [Pubmed]
  30. Targeted ablation of secretin-producing cells in transgenic mice reveals a common differentiation pathway with multiple enteroendocrine cell lineages in the small intestine. Rindi, G., Ratineau, C., Ronco, A., Candusso, M.E., Tsai, M., Leiter, A.B. Development (1999) [Pubmed]
  31. Human cytomegalovirus infection decreases expression of thrombospondin-1 independent of the tumor suppressor protein p53. Cinatl, J., Kotchetkov, R., Scholz, M., Cinatl, J., Vogel, J.U., Driever, P.H., Doerr, H.W. Am. J. Pathol. (1999) [Pubmed]
  32. The suppression of colon cancer cell growth in nude mice by targeting beta-catenin/TCF pathway. Kwong, K.Y., Zou, Y., Day, C.P., Hung, M.C. Oncogene (2002) [Pubmed]
  33. A controlled trial of ganciclovir to prevent cytomegalovirus disease after heart transplantation. Merigan, T.C., Renlund, D.G., Keay, S., Bristow, M.R., Starnes, V., O'Connell, J.B., Resta, S., Dunn, D., Gamberg, P., Ratkovec, R.M. N. Engl. J. Med. (1992) [Pubmed]
  34. Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Heppner, F.L., Greter, M., Marino, D., Falsig, J., Raivich, G., Hövelmeyer, N., Waisman, A., Rülicke, T., Prinz, M., Priller, J., Becher, B., Aguzzi, A. Nat. Med. (2005) [Pubmed]
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