Disease relevance of Hemodiafiltration

• In addition, at amino acid intake rates of > 2 g/kg body weight/day, urea nitrogen removal during continuous hemodiafiltration remains a function of effluent volume, so there is no need to restrict amino acid intake in acute renal failure patients supported with continuous hemodiafiltration [1].
• Lactic acidosis treated with continuous hemodiafiltration and regional citrate anticoagulation [2].
• N-acetylprocainamide intoxication with torsade de pointes treated by high dialysate flow rate continuous arteriovenous hemodiafiltration [3].
• OBJECTIVE: To compare the effects of sodium bicarbonate and lactate for continuous veno-venous hemodiafiltration (CVVHDF) in critically ill patients [4].
• Effect of bicarbonate and lactate buffer on glucose and lactate metabolism during hemodiafiltration in patients with multiple organ failure [4].

High impact information on Hemodiafiltration

• The detoxification capacities of single-pass albumin dialysis (SPAD), the molecular adsorbents recirculation system, (MARS) and continuous veno-venous hemodiafiltration (CVVHDF) were compared in vitro [5].
• The increased urea and creatinine removal did not result in lower pretreatment serum concentrations in the hemodiafiltration group [6].
• Resistance to intercompartmental mass transfer limits beta2-microglobulin removal by post-dilution hemodiafiltration [7].
• In contrast, the clearance of protein-bound solutes relative to urea increased when hemodiafiltration was performed using a larger filter and increasing Q(d) to 300 mL/min while Q(p) was lowered to 50 mL/min [8].
• RESULTS: A mean QS of 134 +/- 20 mL/min (mean FF = 0.65) was attained in post-HDF, and up to 307 +/- 41 mL/min (mean FF = 0.69) in mixed hemodiafiltration [9].

Chemical compound and disease context of Hemodiafiltration

• Pharmacokinetics and the most suitable dosing regimen of fluconazole in critically ill patients receiving continuous hemodiafiltration [10].
• Extraction of protein bound liver failure toxins, such as unconjugated bilirubin, short chain fatty acids, and aromatic amino acids has been reported using hemodiafiltration with albumin in the dialysate, but the characteristics of such a system have not been described [11].
• OBJECTIVE: To determine the linezolid clearance and serum concentrations in a critically ill man receiving continuous venovenous hemodiafiltration (CVVHDF) [12].
• The study objective was to determine whether a phosphodiesterase III inhibitor, olprinone chlorate, is effectively removed by continuous venovenous hemodiafiltration (CVVHDF) in a patient with cardiac and renal failure [13].
• Case report: requirement of supplemental morphine during sedation with propofol in a critically ill patient undergoing hemodiafiltration [14].

Biological context of Hemodiafiltration

• Pharmacokinetics of isepamicin during continuous venovenous hemodiafiltration [15].
• New Method for Phosphate Kinetics Estimation during Hemodialysis and On-Line Hemodiafiltration with Endogenous Reinfusion [16].
• Acid-base balance was preserved during cardiac bypass by the continuous venovenous hemodiafiltration but worsened after disconnection of the extracorporeal circuit, whereas animals treated with methylprednisolone had better pH, Paco(2), and bicarbonate levels by the end of the experiment [17].
• Mechanisms of acid-base homeostasis in acetate and bicarbonate dialysis, lactate hemofiltration and hemodiafiltration [18].
• Continuous venous hemodiafiltration with trisodium citrate anticoagulation in cardiac surgery patients [19].

Anatomical context of Hemodiafiltration

• Detectable amounts of TNF-alpha and IL-1 beta were spontaneously produced by peripheral-blood monocytes 6 h after the end of hemodialysis but not of hemodiafiltration [20].
• Removal of acyclovir during continuous veno-venous hemodialysis and hemodiafiltration with high-efficiency membranes [21].

Associations of Hemodiafiltration with chemical compounds

• To determine bicarbonate, acetate, lactate and total buffer flux, mass balance studies were performed in patients treated with hemodiafiltration using four different combinations of dialysate and substitution fluids [22].
• Pharmacokinetics of cefepime during continuous venovenous hemodiafiltration [23].
• In mixed hemodiafiltration, a newly developed feedback system automatically maintained the transmembrane pressure (TMP) within its highest range of safety (250 to 300 mm Hg) at constant QUF, while ensuring the maximum FF by splitting infusion between pre- and postdilution [9].
• CONCLUSION: Continuous venovenous hemodiafiltration is effective in removing ganciclovir from the blood [24].
• Lithium poisoning treated by high-performance continuous arteriovenous and venovenous hemodiafiltration [25].

Gene context of Hemodiafiltration

• A RIA system for human PTH is presented using a goat antibody (Code name 017-spring-78) against C-terminal hPTH fragments, as well as a human PTH standard from hemodiafiltration of a hyperparathyroid patient [26].
• In conclusion, the findings made in the present study demonstrate that increased OPG in hemodiafiltration patients is only partly due to decreased renal clearance [27].
• Improved iron utilization and reduced erythropoietin resistance by on-line hemodiafiltration [28].
• An ECLVS utilizing hemodiafiltration with albumin dialysis is more effective than conventional hemofiltration in the clearance of TNF-alpha and IL-6 and, therefore, may benefit patients with acute hepatic failure [29].
• Can the clearance of tumor necrosis factor alpha and interleukin 6 be enhanced using an albumin dialysate hemodiafiltration system [29]?

Analytical, diagnostic and therapeutic context of Hemodiafiltration

• The tp can be calculated from the pre-, immediate post- and 30-minute post-dialysis urea concentrations and was 35 minutes (SD 16) in 29 patients undergoing short (149 min) hemodiafiltration and standard (243 min) hemodialysis the following week [30].
• Clearances of the protein-bound solutes phenol red (C(PR)) and indican (C(IN)) were compared to clearances of urea (C(UREA)) during hemofiltration and hemodiafiltration [8].
• Seven patients presenting with symptomatic lithium intoxication were treated by continuous renal replacement therapy (continuous arteriovenous and venovenous hemodiafiltration [CAVHDF and CVVHDF]) [25].
• OBJECTIVE: We compared the ability of peritoneal dialysis, hemofiltration, and continuous hemodiafiltration to remove infused ammonium chloride [31].
• Eight patients were treated with the MARS method in addition to hemodiafiltration (HDF) and standard medical therapy, and 5 patients were in the control group (HDF and standard medical treatment alone) [32].

References