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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor.

Bone morphogenetic protein ( BMP) receptors signal by phosphorylating Smad1, which then associates with Smad4; this complex moves into the nucleus and activates transcription. Here we report the existence of a natural inhibitor of this process, Smad6, a longer version of the previously reported JV15-1. In Xenopus embryos and in mammalian cells, Smad6 specifically blocks signaling by the BMP/Smad1 pathway. Smad6 inhibits BMP/Smad1 signaling without interfering with receptor- mediated phosphorylation of Smad1. Smad6 specifically competes with Smad4 for binding to receptor- activated Smad1, yielding an apparently inactive Smad1-Smad6 complex. Therefore, Smad6 selectively antagonizes BMP- activated Smad1 by acting as a Smad4 decoy.[1]

References

  1. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Hata, A., Lagna, G., Massagué, J., Hemmati-Brivanlou, A. Genes Dev. (1998) [Pubmed]
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