Gene Review:
SMAD1 - SMAD family member 1
Homo sapiens
Synonyms:
BSP-1, BSP1, JV4-1, JV41, MAD homolog 1, ...
- Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts. Mori, Y., Chen, S.J., Varga, J. Arthritis Rheum. (2003)
- Stable overexpression of Smad7 in human melanoma cells inhibits their tumorigenicity in vitro and in vivo. Javelaud, D., Delmas, V., Möller, M., Sextius, P., André, J., Menashi, S., Larue, L., Mauviel, A. Oncogene (2005)
- Modulation of endogenous Smad expression in normal skin fibroblasts by transforming growth factor-beta. Mori, Y., Chen, S.J., Varga, J. Exp. Cell Res. (2000)
- Molecular analyses of the 15q and 18q SMAD genes in pancreatic cancer. Jonson, T., Gorunova, L., Dawiskiba, S., Andrén-Sandberg, A., Stenman, G., ten Dijke, P., Johansson, B., Höglund, M. Genes Chromosomes Cancer (1999)
- Expression of Smad proteins in human colorectal cancer. Korchynskyi, O., Landström, M., Stoika, R., Funa, K., Heldin, C.H., ten Dijke, P., Souchelnytskyi, S. Int. J. Cancer (1999)
- Ectopic expression of phospho-Smad2 in Alzheimer's disease: Uncoupling of the transforming growth factor-beta pathway? Lee, H.G., Ueda, M., Zhu, X., Perry, G., Smith, M.A. J. Neurosci. Res. (2006)
- TGF-beta signal transduction. Massagué, J. Annu. Rev. Biochem. (1998)
- E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression. Chen, C.R., Kang, Y., Siegel, P.M., Massagué, J. Cell (2002)
- Requirement of Bmpr1a for Müllerian duct regression during male sexual development. Jamin, S.P., Arango, N.A., Mishina, Y., Hanks, M.C., Behringer, R.R. Nat. Genet. (2002)
- Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars. Phan, T.T., Lim, I.J., Chan, S.Y., Tan, E.K., Lee, S.T., Longaker, M.T. The Journal of trauma. (2004)
- Changes in Smad expression and subcellular localization in bleomycin-induced pulmonary fibrosis. Venkatesan, N., Pini, L., Ludwig, M.S. Am. J. Physiol. Lung Cell Mol. Physiol. (2004)
- Transforming growth factor-beta and Smad signalling in kidney diseases. Wang, W., Koka, V., Lan, H.Y. Nephrology (Carlton, Vic.) (2005)
- AGEs activate mesangial TGF-beta-Smad signaling via an angiotensin II type I receptor interaction. Fukami, K., Ueda, S., Yamagishi, S., Kato, S., Inagaki, Y., Takeuchi, M., Motomiya, Y., Bucala, R., Iida, S., Tamaki, K., Imaizumi, T., Cooper, M.E., Okuda, S. Kidney Int. (2004)
- Rebamipide inhibits gastric cancer cell growth. Tanigawa, T., Pai, R., Arakawa, T., Tarnawski, A.S. Dig. Dis. Sci. (2007)
- Mammalian twisted gastrulation is essential for skeleto-lymphogenesis. Nosaka, T., Morita, S., Kitamura, H., Nakajima, H., Shibata, F., Morikawa, Y., Kataoka, Y., Ebihara, Y., Kawashima, T., Itoh, T., Ozaki, K., Senba, E., Tsuji, K., Makishima, F., Yoshida, N., Kitamura, T. Mol. Cell. Biol. (2003)
- A component of the ARC/Mediator complex required for TGF beta/Nodal signalling. Kato, Y., Habas, R., Katsuyama, Y., Näär, A.M., He, X. Nature (2002)
- Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein. Stroschein, S.L., Wang, W., Zhou, S., Zhou, Q., Luo, K. Science (1999)
- A FoxO-Smad synexpression group in human keratinocytes. Gomis, R.R., Alarcón, C., He, W., Wang, Q., Seoane, J., Lash, A., Massagué, J. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Molecular basis of oocyte-paracrine signalling that promotes granulosa cell proliferation. Gilchrist, R.B., Ritter, L.J., Myllymaa, S., Kaivo-Oja, N., Dragovic, R.A., Hickey, T.E., Ritvos, O., Mottershead, D.G. J. Cell. Sci. (2006)
- Myricetin induces human osteoblast differentiation through bone morphogenetic protein-2/p38 mitogen-activated protein kinase pathway. Hsu, Y.L., Chang, J.K., Tsai, C.H., Chien, T.T., Kuo, P.L. Biochem. Pharmacol. (2007)
- Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways. Lagna, G., Hata, A., Hemmati-Brivanlou, A., Massagué, J. Nature (1996)
- Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling. Goumans, M.J., Valdimarsdottir, G., Itoh, S., Lebrin, F., Larsson, J., Mummery, C., Karlsson, S., ten Dijke, P. Mol. Cell (2003)
- Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Hata, A., Lo, R.S., Wotton, D., Lagna, G., Massagué, J. Nature (1997)
- The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Kretzschmar, M., Liu, F., Hata, A., Doody, J., Massagué, J. Genes Dev. (1997)
- Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II. Wicks, S.J., Lui, S., Abdel-Wahab, N., Mason, R.M., Chantry, A. Mol. Cell. Biol. (2000)
- Characterization of functional domains within Smad4/DPC4. de Caestecker, M.P., Hemmati, P., Larisch-Bloch, S., Ajmera, R., Roberts, A.B., Lechleider, R.J. J. Biol. Chem. (1997)
- Smad1 pathway is activated in systemic sclerosis fibroblasts and is targeted by imatinib mesylate. Pannu, J., Asano, Y., Nakerakanti, S., Smith, E., Jablonska, S., Blaszczyk, M., ten Dijke, P., Trojanowska, M. Arthritis Rheum. (2008)
- A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction. Kim, R.H., Wang, D., Tsang, M., Martin, J., Huff, C., de Caestecker, M.P., Parks, W.T., Meng, X., Lechleider, R.J., Wang, T., Roberts, A.B. Genes Dev. (2000)
- CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription. Li, L., Xin, H., Xu, X., Huang, M., Zhang, X., Chen, Y., Zhang, S., Fu, X.Y., Chang, Z. Mol. Cell. Biol. (2004)
- Stimulation of type I collagen transcription in human skin fibroblasts by TGF-beta: involvement of Smad 3. Chen, S.J., Yuan, W., Mori, Y., Levenson, A., Trojanowska, M., Varga, J. J. Invest. Dermatol. (1999)
- Interaction of smad3 with a proximal smad-binding element of the human alpha2(I) procollagen gene promoter required for transcriptional activation by TGF-beta. Chen, S.J., Yuan, W., Lo, S., Trojanowska, M., Varga, J. J. Cell. Physiol. (2000)
- The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins. He, J., Tegen, S.B., Krawitz, A.R., Martin, G.S., Luo, K. J. Biol. Chem. (2003)
- Identification of a putative autocrine bone morphogenetic protein-signaling pathway in human ovarian surface epithelium and ovarian cancer cells. Shepherd, T.G., Nachtigal, M.W. Endocrinology (2003)
- The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization. Chacko, B.M., Qin, B., Correia, J.J., Lam, S.S., de Caestecker, M.P., Lin, K. Nat. Struct. Biol. (2001)
- Protein Serine/Threonine Phosphatase PPM1A Dephosphorylates Smad1 in the Bone Morphogenetic Protein Signaling Pathway. Duan, X., Liang, Y.Y., Feng, X.H., Lin, X. J. Biol. Chem. (2006)
- TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. Janknecht, R., Wells, N.J., Hunter, T. Genes Dev. (1998)
- Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. Zhang, Y., Chang, C., Gehling, D.J., Hemmati-Brivanlou, A., Derynck, R. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Two short segments of Smad3 are important for specific interaction of Smad3 with c-Ski and SnoN. Mizuide, M., Hara, T., Furuya, T., Takeda, M., Kusanagi, K., Inada, Y., Mori, M., Imamura, T., Miyazawa, K., Miyazono, K. J. Biol. Chem. (2003)
- Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation. Harada, J., Kokura, K., Kanei-Ishii, C., Nomura, T., Khan, M.M., Kim, Y., Ishii, S. J. Biol. Chem. (2003)
- Selective inhibition of activin receptor-like kinase 5 signaling blocks profibrotic transforming growth factor beta responses in skin fibroblasts. Mori, Y., Ishida, W., Bhattacharyya, S., Li, Y., Platanias, L.C., Varga, J. Arthritis Rheum. (2004)
- Activation of Mps1 promotes transforming growth factor-beta-independent Smad signaling. Zhu, S., Wang, W., Clarke, D.C., Liu, X. J. Biol. Chem. (2007)
- A human Mad protein acting as a BMP-regulated transcriptional activator. Liu, F., Hata, A., Baker, J.C., Doody, J., Cárcamo, J., Harland, R.M., Massagué, J. Nature (1996)
- The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation. Feng, X.H., Zhang, Y., Wu, R.Y., Derynck, R. Genes Dev. (1998)
- Synergistic cooperation of TFE3 and smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor-1 gene. Hua, X., Liu, X., Ansari, D.O., Lodish, H.F. Genes Dev. (1998)
- MDM2 and MDMX inhibit the transcriptional activity of ectopically expressed SMAD proteins. Yam, C.H., Siu, W.Y., Arooz, T., Chiu, C.H., Lau, A., Wang, X.Q., Poon, R.Y. Cancer Res. (1999)
- Regulation mechanisms of retinal pigment epithelial cell migration by the TGF-beta superfamily. Mitsuhiro, M.R., Eguchi, S., Yamashita, H. Acta ophthalmologica Scandinavica. (2003)
- The androgen receptor represses transforming growth factor-beta signaling through interaction with Smad3. Chipuk, J.E., Cornelius, S.C., Pultz, N.J., Jorgensen, J.S., Bonham, M.J., Kim, S.J., Danielpour, D. J. Biol. Chem. (2002)