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Gene Review

BMP1  -  bone morphogenetic protein 1

Homo sapiens

Synonyms: OI13, PCOLC, PCP, PCP2, TLD
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Disease relevance of BMP1


Psychiatry related information on BMP1


High impact information on BMP1


Chemical compound and disease context of BMP1


Biological context of BMP1


Anatomical context of BMP1


Associations of BMP1 with chemical compounds

  • Surprisingly, although BMP1 has long been known to be Ca(2+)-dependent, a property previously assumed to apply to all members of the subgroup, mTLL1 is demonstrated to be independent of Ca(2) levels in its ability to cleave some, but not all, substrates [21].
  • Regulation of neural cell adhesion molecule and L1 by the transforming growth factor-beta superfamily. Selective effects of the bone morphogenetic proteins [28].
  • To address the relationship between bone morphogenetic protein (BMP) signaling and gap junction-mediated intercellular communication, we examined the effects of BMP-2 and a gap junction blocker 18 alpha glycyrrhetinic acid (18alpha-GCA) on mesenchymal cell condensation and chondrogenic differentiation in an in vitro chondrogenic model [29].
  • Initiation of heterotopic osteogenesis in primates after chromatographic adsorption of osteogenin, a bone morphogenetic protein, onto porous hydroxyapatite [30].
  • These factors include the influence of root conditioning, occlusal loading, BMP dose, and the release characteristics of the carrier as well as the suitability of the model to evaluate the efficacy of BMPs [31].

Physical interactions of BMP1


Enzymatic interactions of BMP1


Regulatory relationships of BMP1


Other interactions of BMP1

  • Each of the three (BMP-1, BMP-2A, and BMP-3) appears to be independently capable of inducing the formation of cartilage in vivo [42].
  • The data support a previously suggested mechanism of PCPE-1 whereby PCPE-1 interacts with procollagen, but in addition, the CUB3 domain of BMP-1 appears to augment the interaction [43].
  • Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts [26].
  • BMP-2 and -4 belong to a subgroup of BMPs using the BMP receptors Alk-3 or -6 [3].
  • In this study, we examined the effects on human myeloma cells of BMP-6 and -7, members of a different BMP subgroup, which mainly utilize Alk-2 as their receptor [3].

Analytical, diagnostic and therapeutic context of BMP1


  1. Mapping of the bone morphogenetic protein 1 gene (BMP1) to 8p21: removal of BMP1 from candidacy for the bone disorder in Langer-Giedion syndrome. Yoshiura, K., Tamura, T., Hong, H.S., Ohta, T., Soejima, H., Kishino, T., Jinno, Y., Niikawa, N. Cytogenet. Cell Genet. (1993) [Pubmed]
  2. Bone morphogenetic proteins and bFGF exert opposing regulatory effects on PTHrP expression and inorganic pyrophosphate elaboration in immortalized murine endochondral hypertrophic chondrocytes (MCT cells). Terkeltaub, R.A., Johnson, K., Rohnow, D., Goomer, R., Burton, D., Deftos, L.J. J. Bone Miner. Res. (1998) [Pubmed]
  3. Bone morphogenetic protein-5, -6 and -7 inhibit growth and induce apoptosis in human myeloma cells. Ro, T.B., Holt, R.U., Brenne, A.T., Hjorth-Hansen, H., Waage, A., Hjertner, O., Sundan, A., Borset, M. Oncogene (2004) [Pubmed]
  4. Expression of bone morphogenetic proteins by osteoinductive and non-osteoinductive human osteosarcoma cells. Raval, P., Hsu, H.H., Schneider, D.J., Sarras, M.P., Masuhara, K., Bonewald, L.F., Anderson, H.C. J. Dent. Res. (1996) [Pubmed]
  5. Bone morphogenetic protein type IB receptor is progressively expressed in malignant glioma tumours. Yamada, N., Kato, M., ten Dijke, P., Yamashita, H., Sampath, T.K., Heldin, C.H., Miyazono, K., Funa, K. Br. J. Cancer (1996) [Pubmed]
  6. Bone morphogenetic proteins are overexpressed in the bone marrow of primary myelofibrosis and are apparently induced by fibrogenic cytokines. Bock, O., Höftmann, J., Theophile, K., Hussein, K., Wiese, B., Schlué, J., Kreipe, H. Am. J. Pathol. (2008) [Pubmed]
  7. Detection of two transforming growth factor-beta-related morphogens, bone morphogenetic proteins-4 and -5, in RNA of multiple sclerosis and Creutzfeldt-Jakob disease lesions. Deininger, M., Meyermann, R., Schluesener, H. Acta Neuropathol. (1995) [Pubmed]
  8. Identification and quantification of phencyclidine pyrolysis products formed during smoking. Lue, L.P., Scimeca, J.A., Thomas, B.F., Martin, B.R. Journal of analytical toxicology. (1986) [Pubmed]
  9. Violence associated with phencyclidine abuse. Fauman, M.A., Fauman, B.J. The American journal of psychiatry. (1979) [Pubmed]
  10. Acute phencyclidine (PCP) intoxication: psychopathology and prognosis. Yesavage, J.A., Freman, A.M. The Journal of clinical psychiatry. (1978) [Pubmed]
  11. Glial-neuronal interactions are impaired in the schizophrenia model of repeated MK801 exposure. Kondziella, D., Brenner, E., Eyjolfsson, E.M., Markinhuhta, K.R., Carlsson, M.L., Sonnewald, U. Neuropsychopharmacology (2006) [Pubmed]
  12. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Babitt, J.L., Huang, F.W., Wrighting, D.M., Xia, Y., Sidis, Y., Samad, T.A., Campagna, J.A., Chung, R.T., Schneyer, A.L., Woolf, C.J., Andrews, N.C., Lin, H.Y. Nat. Genet. (2006) [Pubmed]
  13. Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred. Newman, J.H., Wheeler, L., Lane, K.B., Loyd, E., Gaddipati, R., Phillips, J.A., Loyd, J.E. N. Engl. J. Med. (2001) [Pubmed]
  14. Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Howe, J.R., Bair, J.L., Sayed, M.G., Anderson, M.E., Mitros, F.A., Petersen, G.M., Velculescu, V.E., Traverso, G., Vogelstein, B. Nat. Genet. (2001) [Pubmed]
  15. Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1. Thomas, J.T., Kilpatrick, M.W., Lin, K., Erlacher, L., Lembessis, P., Costa, T., Tsipouras, P., Luyten, F.P. Nat. Genet. (1997) [Pubmed]
  16. Enhancement of bone morphogenetic protein-2-induced new bone formation in mice by the phosphodiesterase inhibitor pentoxifylline. Horiuchi, H., Saito, N., Kinoshita, T., Wakabayashi, S., Tsutsumimoto, T., Takaoka, K. Bone (2001) [Pubmed]
  17. Expression of bone morphogenetic proteins in acute promyelocytic leukemia before and after combined all trans-retinoic acid and cytotoxic treatment. Grcević, D., Marusić, A., Grahovac, B., Jaksić, B., Kusec, R. Leuk. Res. (2003) [Pubmed]
  18. Retinoic acid enhances expression of bone morphogenetic protein-2 in human adenocarcinoma cell line (HSG-S8). Hatakeyama, S., Ohara-Nemoto, Y., Kyakumoto, S., Satoh, M. Biochem. Mol. Biol. Int. (1996) [Pubmed]
  19. RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation. Fromigu??, O., Ha??, E., Modrowski, D., Bouvet, S., Jacquel, A., Auberger, P., Marie, P.J. Cell Death Differ. (2006) [Pubmed]
  20. Bone morphogenetic proteins (BMPs) induce epithelial differentiation of NT2D1 human embryonal carcinoma cells. Caricasole, A., Ward-van Oostwaard, D., Zeinstra, L., van den Eijnden-van Raaij, A., Mummery, C. Int. J. Dev. Biol. (2000) [Pubmed]
  21. Mammalian Tolloid-like 1 Binds Procollagen C-proteinase Enhancer Protein 1 and Differs from Bone Morphogenetic Protein 1 in the Functional Roles of Homologous Protein Domains. Ge, G., Zhang, Y., Steiglitz, B.M., Greenspan, D.S. J. Biol. Chem. (2006) [Pubmed]
  22. Structural organization and genetic localization of the human bone morphogenetic protein 1/mammalian tolloid gene. Takahara, K., Lee, S., Wood, S., Greenspan, D.S. Genomics (1995) [Pubmed]
  23. Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP3. Tabas, J.A., Zasloff, M., Wasmuth, J.J., Emanuel, B.S., Altherr, M.R., McPherson, J.D., Wozney, J.M., Kaplan, F.S. Genomics (1991) [Pubmed]
  24. A role for bone morphogenetic proteins in the induction of cardiac myogenesis. Schultheiss, T.M., Burch, J.B., Lassar, A.B. Genes Dev. (1997) [Pubmed]
  25. Osteogenin and recombinant bone morphogenetic protein 2B are chemotactic for human monocytes and stimulate transforming growth factor beta 1 mRNA expression. Cunningham, N.S., Paralkar, V., Reddi, A.H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  26. Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts. Tardif, G., Hum, D., Pelletier, J.P., Boileau, C., Ranger, P., Martel-Pelletier, J. Arthritis Rheum. (2004) [Pubmed]
  27. Transforming growth factor-beta regulation of bone morphogenetic protein-1/procollagen C-proteinase and related proteins in fibrogenic cells and keratinocytes. Lee, S., Solow-Cordero, D.E., Kessler, E., Takahara, K., Greenspan, D.S. J. Biol. Chem. (1997) [Pubmed]
  28. Regulation of neural cell adhesion molecule and L1 by the transforming growth factor-beta superfamily. Selective effects of the bone morphogenetic proteins. Perides, G., Safran, R.M., Downing, L.A., Charness, M.E. J. Biol. Chem. (1994) [Pubmed]
  29. Bone morphogenetic protein-2 modulation of chondrogenic differentiation in vitro involves gap junction-mediated intercellular communication. Zhang, W., Green, C., Stott, N.S. J. Cell. Physiol. (2002) [Pubmed]
  30. Initiation of heterotopic osteogenesis in primates after chromatographic adsorption of osteogenin, a bone morphogenetic protein, onto porous hydroxyapatite. Ripamonti, U., Yeates, L., van den Heever, B. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  31. Factors that modulate the effects of bone morphogenetic protein-induced periodontal regeneration: a critical review. King, G.N., Cochran, D.L. J. Periodontol. (2002) [Pubmed]
  32. Critical molecular switches involved in BMP-2-induced osteogenic differentiation of mesenchymal cells. Ryoo, H.M., Lee, M.H., Kim, Y.J. Gene (2006) [Pubmed]
  33. Effect of bone morphogenetic protein-6 on haemopoietic stem cells and cytokine production in normal human bone marrow stroma. Ahmed, N., Sammons, J., Carson, R.J., Khokher, M.A., Hassan, H.T. Cell Biol. Int. (2001) [Pubmed]
  34. Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors. Nohno, T., Ishikawa, T., Saito, T., Hosokawa, K., Noji, S., Wolsing, D.H., Rosenbaum, J.S. J. Biol. Chem. (1995) [Pubmed]
  35. Enhanced osteogenic promotion around dental implants with synthetic binding motif mimicking bone morphogenetic protein (BMP)-2. Seol, Y.J., Park, Y.J., Lee, S.C., Kim, K.H., Lee, J.Y., Kim, T.I., Lee, Y.M., Ku, Y., Rhyu, I.C., Han, S.B., Chung, C.P. Journal of biomedical materials research. Part A. (2006) [Pubmed]
  36. Paired basic/Furin-like proprotein convertase cleavage of Pro-BMP-1 in the trans-Golgi network. Leighton, M., Kadler, K.E. J. Biol. Chem. (2003) [Pubmed]
  37. Fibroblasts of spinal ligaments pathologically differentiate into chondrocytes induced by recombinant human bone morphogenetic protein-2: morphological examinations for ossification of spinal ligaments. Hoshi, K., Amizuka, N., Sakou, T., Kurokawa, T., Ozawa, H. Bone (1997) [Pubmed]
  38. Mechanism for the action of bone morphogenetic proteins and regulation of their activity. Ebara, S., Nakayama, K. Spine. (2002) [Pubmed]
  39. Substrate-specific modulation of a multisubstrate proteinase. C-terminal processing of fibrillar procollagens is the only BMP-1-dependent activity to be enhanced by PCPE-1. Moali, C., Font, B., Ruggiero, F., Eichenberger, D., Rousselle, P., François, V., Oldberg, A., Bruckner-Tuderman, L., Hulmes, D.J. J. Biol. Chem. (2005) [Pubmed]
  40. Differential expression of bone and cartilage related genes in fibrodysplasia ossificans progressiva, myositis ossificans traumatica, and osteogenic sarcoma. Shafritz, A.B., Kaplan, F.S. Clin. Orthop. Relat. Res. (1998) [Pubmed]
  41. Bone morphogenetic protein (BMP)-2 enhances the expression of type II collagen and aggrecan in chondrocytes embedded in alginate beads. Gründer, T., Gaissmaier, C., Fritz, J., Stoop, R., Hortschansky, P., Mollenhauer, J., Aicher, W.K. Osteoarthr. Cartil. (2004) [Pubmed]
  42. Novel regulators of bone formation: molecular clones and activities. Wozney, J.M., Rosen, V., Celeste, A.J., Mitsock, L.M., Whitters, M.J., Kriz, R.W., Hewick, R.M., Wang, E.A. Science (1988) [Pubmed]
  43. Identification of the minimal domain structure of bone morphogenetic protein-1 (BMP-1) for chordinase activity: chordinase activity is not enhanced by procollagen C-proteinase enhancer-1 (PCPE-1). Petropoulou, V., Garrigue-Antar, L., Kadler, K.E. J. Biol. Chem. (2005) [Pubmed]
  44. A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7. Hahn, G.V., Cohen, R.B., Wozney, J.M., Levitz, C.L., Shore, E.M., Zasloff, M.A., Kaplan, F.S. Genomics (1992) [Pubmed]
  45. Gene therapy for new bone formation using adeno-associated viral bone morphogenetic protein-2 vectors. Chen, Y., Luk, K.D., Cheung, K.M., Xu, R., Lin, M.C., Lu, W.W., Leong, J.C., Kung, H.F. Gene Ther. (2003) [Pubmed]
  46. Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells. Zhang, S., Fantozzi, I., Tigno, D.D., Yi, E.S., Platoshyn, O., Thistlethwaite, P.A., Kriett, J.M., Yung, G., Rubin, L.J., Yuan, J.X. Am. J. Physiol. Lung Cell Mol. Physiol. (2003) [Pubmed]
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